Product Name:

Aquaporin 3


Product Number:

ab-nn201-1

Price:

Regular price
$89.00
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$89.00

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Target Full Name: Aquaporin 3

Target Alias: AQP3; AQP 3; AQP-3; Aqp3; AQP3_HUMAN; Aquaglyceroporin-3; Aquaporin 3 (GIL blood group); Aquaporin 3 (Gill blood group); GIL; Gill blood group

Product Type Specific: Aquaporin pan-specific antibody

Antibody Code: NN201-1

Antibody Target Type: Pan-specific

Protein UniProt: Q92482

Protein SigNET: Q92482

Antibody Type: Polyclonal

Antibody Host Species: Rabbit

Antibody Ig Isotype Clone: N/A

Antibody Immunogen Source: Produced against the C-terminal peptide (Sequence N-CHLEQPPPSTEAENVKLAHMKHKEQI) of rat aquaporin 3

Antibody Modification: Aquaporin pan-specific antibody

Antibody Concentration: 1 mg/ml

Storage Buffer: Phosphate buffered saline, 50% glycerol, 0.09% sodium azide

Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.

Product Use: Western blotting | Immunohistochemistry | ICC/Immunofluorescence

Antibody Dilution Recommended: WB (1:2000), ICC/IF (1:400); optimal dilutions for assays should be determined by the user.

Antibody Potency: Detects a ~31.5 kDa protein in cell and tissue lysates by Western blotting. May detect larger glycosylated ~35-50 kDa proteins.

Antibody Species Reactivity: Human | Mouse | Rat

Antibody Positive Control: 0.5 µg/ml of SPC-504 was sufficient for detection of aquaporin 3 in 10 µg of rat kidney tissue lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.

Scientific Background: Aquaporins selectively conduct water molecules in and out of the cell, while preventing the passage of ions and other solutes. Known as water channels, they are integral membrane pore proteins (1, 2). Aquaporin 3 is found in the basolateral cell membrane of principal collecting duct cells and provide a pathway for water to exit these cells (3). AQP3 gene expression is not regulated by vasopressin (4).