Product Name:
p38g-2
Product Number:
ab-nk059-3
Target Full Name: Mitogen-activated protein-serine kinase p38 gamma; Mitogen-activated protein kinase 12
Target Alias: ERK3; ERK5; ERK6; MAPK12; MK12; p38 MAPK-gamma; PRKM12; SAPK3; Stress-activated protein kinase-3; CCDS14089.1; ENSG00000188130
Product Type Specific: Protein kinase pan-specific antibody
Antibody Code: NK059-4
Antibody Target Type: Pan-specific
Protein UniProt: P53778
Protein SigNET: P53778
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Antibody Immunogen Source: Human p38g MAPK (MAPK12, ERK6) sequence peptide Cat. No.: PE-01AYK90
Antibody Immunogen Sequence: CVQKYDDSFDDVDRTL
Antibody Immunogen Description: Corresponds to amino acid residues V323 to L337; Post-kinase last alpha-chain
Production Method: Corresponds to amino acid residues V323 to L337; Post-kinase last alpha-chain
Antibody Modification: Protein kinase pan-specific antibody
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH 7.4, 0.05% Thimerasol
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Antibody microarray
Antibody Dilution Recommended: 1 µg/ml for immunoblotting
Antibody Potency: Medium-strong immunoreactivity with recombinant human p38g on protein dot blots.
Antibody Species Reactivity: Human; Mouse
Antibody Positive Control: The observed molecular mass of the processed target protein on SDS-PAGE gels is reported to be around 38-42 kDa.
Antibody Specificity: Very high
Antibody Cross Reactivity: Medium-strong with recombinant human p38b, very weak immunoreactivity with p38d, and no immunoreactivity with p38a.
Related Product 1: p38g-2 blocking peptide
Related Product 2: p38 pan-specific antibody (Cat. No.: AB-NK120-5)
Related Product 3: p38g-1 pan-specific antibody (Cat. No.: AB-NK059-3)
Related Product 4: p38g-3 pan-specific antibody (Cat. No.: AB-NK059-5)
Related Product 5: p38HOG-NT (p38a-5) pan-specific antibody (Cat. No.: AB-NK120-10)
Related Product 6: p38SelectideA - p38a MAPK (MAPK14) protein kinase substrate peptide
Related Product 7: p38Subtide - p38a MAPK (MAPK14) protein kinase substrate peptide
Related Product 8: p38 MAPK KinSub - p38 MAPK peptide substrate
Scientific Background: p38g (MAPK12, ERK6) is a protein-serine/threonine kinase of the CMGC group and p38 MAPK family. This kinase is moderate to highly expressed in most tested human tissues except in the pituitary, spinal cord and vagina, where it is notably absent. p38g is activated by phosphorylation at Y185 and probably T183. p38g is activated in response to stress. It has been linked with the development of inflammation, autoimmunity, diabetes and cancer. It functions as a signal transducer during myoblasts to myotubes differentiation. Enforced localization of p38g in the nucleus or cytoplasm markedly attenuates the ability of the kinase to induce cell cycle arrest in fibroblasts. p38g increases basal glucose uptake and decreases DNP- and contraction-stimulated glucose uptake, partially by affecting levels of glucose transporter expression in skeletal muscle. p38g overexpression is linked with highly metastatic breast cancer cell lines, and its expression is associated with the metastatic states of breast tumour samples. The gene was found to be deregulated in uterine leiomyoma. Loss of function may be important to confer survival and inhibit apoptosis for tumour cells.
