Product Name:
GSK3a (275-288) pS278+pY279+pS282+pY284+pY285
Product Number:
pe-04auq95
Peptide Name: GSK3a (275-288) pS278+pY279+pS282+pY284+pY285
Product Use: This phosphopeptide may be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T loop region between subdomains VII and VIII. S278 and Y279 phosphorylation stimulate phosphotransferase activity, promote nuclear localization, and regulate cell growth, apoptosis, transcription, protein stability, and molecular association. S282, Y284 and Y285 phosphorylation are predicted to be inhibitory for phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: PNV-pS-pY-IC-pS-R-pY-pY-RAP
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 2304.2 Da
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C