Product Name:
InsR (1186-1192) pY1189
Product Number:
pe-04akm99
Peptide Name: InsR (1186-1192) pY1189
Product Use: Blocking peptide for use with the InsR-pY1189 rabbit polyclonal antibody (Cat. No.: AB-PK663) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T-loop between subdomains VII and VIII. Y1189 phosphorylation stimulates phosphotransferase activity, receptor internalization and induces interaction with GRB7, SOCS1, IRS2 and PTP1B.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: ETD-pY-YRK
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1228.19 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: InsR - pY1189 phosphosite-specific antibody (Cat. No.: AB-PK663)