Product Name:
WASP-pY291
Product Number:
ab-pn545
Target Full Name: Wiskott-Aldrich syndrome protein
Product Type Specific: WASP phosphosite-specific antibody
Antibody Code: PN545
Antibody Target Type: Phosphosite-specific
Antibody Phosphosite: Y291
Protein UniProt: P42768
Protein SigNET: P42768
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Antibody Immunogen Source: Human WASP sequence peptide Cat. No.: PE-04AFC99
Antibody Immunogen Sequence: KLI(pY)DFI(bA)C
Antibody Immunogen Description: Corresponds to amino acid residues K288 to I294; In the PBD domain
Production Method: Corresponds to amino acid residues K288 to I294; In the PBD domain
Antibody Modification: WASP phosphosite-specific antibody
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH 7.4, 0.05% Thimerasol
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Antibody microarray
Antibody Dilution Recommended: 2 µg/ml for immunoblotting
Antibody Species Reactivity: Human
Antibody Positive Control: The observed molecular mass of the processed target protein on SDS-PAGE gels is reported to be around 54-62 kDa.
Antibody Specificity: Very high
Antibody Cross Reactivity: No significant cross-reactive proteins in sea star oocytes.
Related Product 1: WASP-pY291 blocking peptide
Scientific Background: WASP is a member of the Wiskott-Aldrich syndrome (WAS) family of proteins. It is a cytoplasmic protein expressed exclusively in hematopoietic cells. WASP transduces signals from surface receptors to the actin cytoskeleton. It associates with the small GTPase, Cdc42, to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. It is mutated in Wiskott-Aldrich syndrome,which is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia.
