Product Name:
TGM2-pY369
Product Number:
ab-pn541
Target Full Name: Protein-glutamine gamma-glutamyltransferase 2
Target Alias: C polypeptide; G-ALPHA-h; GNAH; Protein-glutamine gamma-glutamyltransferase 2; protein-glutamine-gamma-glutamyltransferase; TG(C); TG2; TGase C; TGase H; TGase-2; TGase-H; TGC; TGM2; Tissue transglutaminase; transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase); Transglutaminase C; Transglutaminase H; Transglutaminase-2
Product Type Specific: TGM2 phosphosite-specific antibody
Antibody Code: PN541
Antibody Target Type: Phosphosite-specific
Antibody Phosphosite: Y369
Protein UniProt: P21980
Protein SigNET: P21980
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Antibody Immunogen Source: Human TGM2 sequence peptide Cat. No.: PE-04ADQ95
Antibody Immunogen Sequence: EGT(pY)CCG(bA)C
Antibody Immunogen Description: Corresponds to amino acid residues E366 to G372; In the region between the Transglut_core and Transglut_C domains. This is the major in vivo phosphorylation site in TGM2.
Production Method: Corresponds to amino acid residues E366 to G372; In the region between the Transglut_core and Transglut_C domains. This is the major in vivo phosphorylation site in TGM2.
Antibody Modification: TGM2 phosphosite-specific antibody
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH 7.4, 0.05% Thimerasol
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Antibody microarray
Antibody Dilution Recommended: 2 µg/ml for immunoblotting
Antibody Potency: Strong immunoreactivity of a target-sized protein by Western blotting in HepG2 cells, and weak detection in Jurkat cells.
Antibody Species Reactivity: Human
Antibody Positive Control: The observed molecular mass of the processed target protein on SDS-PAGE gels is reported to be around 82-92 kDa.
Antibody Specificity: High
Antibody Cross Reactivity: In HepG2 cells, insulin decreases 75 and 58 kDa proteins. Almost no significant cross-reactivities were detected in Jurkat and T98G cells.
Related Product 1: TGM2-pY369 blocking peptide
Scientific Background: TGM2 is a member of the transglutaminase family of enzymes that catalyzes the crosslinking of proteins and the conjugation of polyamines to proteins. The protein acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis.
