Product Name:
STAM2-pY374
Product Number:
ab-pn538
Target Full Name: Signal transducing adapter molecule 2
Target Alias: DKFZp564C047; HBP; Hrs-binding protein; HSE1 homolog; Signal transducing adapter molecule 2; signal transducing adaptor molecule (SH3 domain and ITAM motif) 2; STAM-2; STAM-like protein containing SH3 and ITAM domains 2; STAM2; STAM2A; STAM2B
Product Type Specific: STAM2 phosphosite-specific antibody
Antibody Code: PN538
Antibody Target Type: Phosphosite-specific
Antibody Phosphosite: Y374
Protein UniProt: O75886
Protein SigNET: O75886
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Antibody Immunogen Source: Human STAM2 sequence peptide Cat. No.: PE-04AEF95
Antibody Immunogen Sequence: YSV(pY)SKL(bA)C
Antibody Immunogen Description: Corresponds to amino acid residues Y371 to L377; In the C-terminal half of the protein. This is the second major in vivo phosphorylation site in STAM2.
Production Method: Corresponds to amino acid residues Y371 to L377; In the C-terminal half of the protein. This is the second major in vivo phosphorylation site in STAM2.
Antibody Modification: STAM2 phosphosite-specific antibody
Antibody Concentration: 0.5 (/ 1.0) / 0.05 mg/ml
Storage Buffer: Phosphate buffered saline pH 7.4, 0.05% Thimerasol
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Antibody microarray
Antibody Dilution Recommended: 2 µg/ml for immunoblotting
Antibody Species Reactivity: Human
Antibody Positive Control: The observed molecular mass of the processed target protein on SDS-PAGE gels is reported to be around 65-72 kDa.
Related Product 1: STAM2-pY374 blocking peptide
Scientific Background: STAM2 (STAMP2) is involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signalling leading to DNA synthesis and MYC induction. It may also play a role in T-cell development, and appears to be involved in down-regulation of receptor-tyrosine kinases via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex).
