Product Name:
snRNP 70-pY126
Product Number:
ab-pn537
Target Full Name: U1 small nuclear ribonucleoprotein 70 kDa
Target Alias: RNPU1Z; RPU1; RU17; small nuclear ribonucleoprotein 70kDa (U1); Snp1; SNRNP70; SNRP70; U1 small nuclear ribonucleoprotein 70 kDa; U1 snRNP 70 kDa; U1-70K; U170K; U1AP; U1AP1; U1RNP
Product Type Specific: snRNP 70 phosphosite-specific antibody
Antibody Code: PN537
Antibody Target Type: Phosphosite-specific
Antibody Phosphosite: Y126
Protein UniProt: P08621
Protein SigNET: P08621
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Antibody Immunogen Source: Human snRNP 70 sequence peptide Cat. No.: PE-04AFF99
Antibody Immunogen Sequence: FEV(pY)GPI(bA)C
Antibody Immunogen Description: Corresponds to amino acid residues F123 to I129; In the RRM_1 domain. This is the major in vivo phosphorylation site in snRNP70.
Production Method: Corresponds to amino acid residues F123 to I129; In the RRM_1 domain. This is the major in vivo phosphorylation site in snRNP70.
Antibody Modification: snRNP 70 phosphosite-specific antibody
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH 7.4, 0.05% Thimerasol
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Antibody microarray
Antibody Dilution Recommended: 2 µg/ml for immunoblotting
Antibody Species Reactivity: Human
Antibody Positive Control: The observed molecular mass of the processed target protein on SDS-PAGE gels is reported to be around 60-65 kDa.
Antibody Specificity: Very high
Antibody Cross Reactivity: No significant cross-reactive proteins detected in HeLa and T98G cells.
Related Product 1: snRNP 70-pY126 blocking peptide
Scientific Background: SNRNP70 is part of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and spliceosome assembly. SNRNP70 binds to the loop I region of U1-snRNA.
