Product Name:
PLCG2-pY759
Product Number:
ab-pn531
Target Full Name: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2
Target Alias: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2; Phosphoinositide phospholipase C-gamma-2; phospholipase C gamma 2; phospholipase C, gamma 2 (phosphatidylinositol-specific); phospholipase C, gamma 2 (phosphatidylyinositol-specific); Phospholipase C-gamma-2; Phospholipase C-IV; PLC-gamma-2; PLC-IV; PLCG2
Product Type Specific: Phospholipase phosphosite-specific antibody
Antibody Code: PN531
Antibody Target Type: Phosphosite-specific
Antibody Phosphosite: Y759
Protein UniProt: P16885
Protein SigNET: P16885
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Antibody Immunogen Source: Human PLCG2 (PLC R) sequence peptide Cat. No.: PE-04ADH99
Antibody Immunogen Sequence: SRM(pY)VDP(bA)C
Antibody Immunogen Description: Corresponds to amino acid residues S756 to P762; Near the end of the second SH2 domain in the protein. One of the major in vivo phosphorylation sites in PLCG2.
Production Method: Corresponds to amino acid residues S756 to P762; Near the end of the second SH2 domain in the protein. One of the major in vivo phosphorylation sites in PLCG2.
Antibody Modification: Phospholipase phosphosite-specific antibody
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH 7.4, 0.05% Thimerasol
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Antibody microarray
Antibody Dilution Recommended: 2 µg/ml for immunoblotting
Antibody Species Reactivity: Human
Antibody Positive Control: The observed molecular mass of the processed target protein on SDS-PAGE gels is reported to be around 140-160 kDa.
Related Product 1: PLCG2-pY759 blocking peptide
Related Product 2: PLCG1-pY783 phosphosite-specific antibody (Cat. No.: AB-PN530)
Scientific Background: PLCG2 mediates the production of the second messenger molecules diacylglycerol (DAG) and 1D-myo-inositol 1,4,5-trisphosphate (IP3) from the hydrolysis of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate. It becomes activated in response to ligand-mediated activation of receptor-type receptor-tyrosine kinases and is calcium-activated.
