Product Name:
HSP90AB1-pY484
Product Number:
ab-pn520
Target Full Name: Heat shock protein HSP 90-beta
Target Alias: D6S182; FLJ26984; Heat shock 84 kDa; heat shock 90kD protein 1, beta; heat shock 90kDa protein 1, beta; heat shock protein 90kDa alpha (cytosolic), class B member 1; heat shock protein beta; Heat shock protein HSP 90-beta; HS90B; HSP 84; HSP 90; HSP84; HSP90-BETA; HSP90AB1; HSP90B; HSPC2; HSPCB
Product Type Specific: Heat shock protein phosphosite-specific antibody
Antibody Code: PN520
Antibody Target Type: Phosphosite-specific
Antibody Phosphosite: Y484
Protein UniProt: P08238
Protein SigNET: P08238
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Antibody Immunogen Source: Human HSP90AB1 (HSP90B; HSP90-beta) sequence peptide Cat. No.: PE-04AFE99
Antibody Immunogen Sequence: KSI(pY)YIT(bA)C
Antibody Immunogen Description: Corresponds to amino acid residues K481 to T487; In the middle of the HSP90 domain. This is the major in vivo phosphorylation site in HSP90AB1.
Production Method: Corresponds to amino acid residues K481 to T487; In the middle of the HSP90 domain. This is the major in vivo phosphorylation site in HSP90AB1.
Antibody Modification: Heat shock protein phosphosite-specific antibody
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH 7.4, 0.05% Thimerasol
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Antibody microarray
Antibody Dilution Recommended: 2 µg/ml for immunoblotting
Antibody Potency: Medium immunoreactivity with immunogen peptide on dot blots.
Antibody Species Reactivity: Human
Antibody Positive Control: The observed molecular mass of the processed target protein on SDS-PAGE gels is reported to be around 90-95 kDa.
Antibody Specificity: High-very high
Antibody Cross Reactivity: No significant cross-reactive proteins detected in A431 and Jurkat cells.
Related Product 1: HSP90AB1-pY484 blocking peptide
Related Product 2: HSP90 pan-specific antibody (Cat. No.: AB-NN061-16)
Related Product 3: HSP90 complex pan-specific antibody (Cat. No.: AB-NN061-18)
Related Product 4: HSP90 alpha pan-specific antibody (Cat. No.: AB-NN061-19)
Related Product 5: HSP90 alpha/beta pan-specific antibody (Cat. No.: AB-NN061-2)
Related Product 6: HSP90 pan-specific antibody (Cat. No.: AB-NN061-3)
Related Product 7: HSP90 pan-specific antibody (Cat. No.: AB-NN061-4)
Related Product 8: HSP90 (total) pan-specific antibody (Cat. No.: AB-NN061-9)
Related Product 9: HSP90 alpha pan-specific antibody (Cat. No.: AB-NN164)
Related Product 10: Hsp90 beta pan-specific antibody (Cat. No.: AB-NN165-1)
Scientific Background: HSP90-beta is a molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved in diverse cellular functions such as cycle control. It induces conformational changes in the client proteins in an ATP-dependent process as an ATPase, and causes their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.
