Product Name:
ErbB2IP-pY1104
Product Number:
ab-pn513
Target Full Name: Protein LAP2
Target Alias: Densin-180-like protein; erbb2 interacting protein; Erbb2-interacting protein; ErbB2IP; ERBIN; KIAA1225; LAP2; Protein LAP2
Product Type Specific: ErbB2IP phosphosite-specific antibody
Antibody Code: PN513
Antibody Target Type: Phosphosite-specific
Antibody Phosphosite: Y1104
Protein UniProt: Q96RT1
Protein SigNET: Q96RT1
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Antibody Immunogen Source: Human ErbB2IP (Erbin) sequence peptide Cat. No.: PE-04AER99
Antibody Immunogen Sequence: EGD(pY)LSY(bA)C
Antibody Immunogen Description: Corresponds to amino acid residues E1101 to Y1107; In the C-terminal quarter of the protein before the PDZ domain. The major in vivo phosphorylation site in ErbB2IP.
Production Method: Corresponds to amino acid residues E1101 to Y1107; In the C-terminal quarter of the protein before the PDZ domain. The major in vivo phosphorylation site in ErbB2IP.
Antibody Modification: ErbB2IP phosphosite-specific antibody
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH 7.4, 0.05% Thimerasol
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Antibody microarray
Antibody Dilution Recommended: 2 µg/ml for immunoblotting
Antibody Potency: Medium-weak immunoreactivity of a target-sized protein by Western blotting in HEK-293 and HeLa cells. Very strong immunoreactivity with immunogen peptide on dot blots.
Antibody Species Reactivity: Human
Antibody Positive Control: The observed molecular mass of the processed target protein on SDS-PAGE gels is reported to be around 170-180 kDa.
Antibody Specificity: High
Antibody Cross Reactivity: No significant cross-reactive proteins detected in HEK-293 and HeLa cells, except for a very strong ~250 kDa cross-reactive protein in HeLa cells.
Related Product 1: ErbB2IP-pY1104 blocking peptide
Scientific Background: ErbB2IP acts as an adapter for the receptor ErbB2, in epithelia. By binding the unphosphorylated 'Y1248' of receptor ErbB2, it may contribute to stabilize this unphosphorylated state. It Inhibits NOD2-dependent NF-kappa-B signalling and proinflammatory cytokine secretion.
