Product Name:
ANXA2-pY238
Product Number:
ab-pn504
Target Full Name: Annexin A2
Target Alias: Annexin II; Annexin-2; ANX2; ANX2L4; anxa 2; ANXA2; CAL1H; Calpactin I heavy chain; calpactin I heavy polypeptide; Calpactin-1 heavy chain; chromobindin 8; Chromobindin-8; LIP2; Lipocortin II; LPC2; LPC2D; p36; PAP-IV; Placental anticoagulant protein IV; Protein I
Product Type Specific: Annexin phosphosite-specific antibody
Antibody Code: PN504
Antibody Target Type: Phosphosite-specific
Antibody Phosphosite: Y238
Protein UniProt: P07355
Protein SigNET: P07355
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Antibody Immunogen Source: Human ANXA2 sequence peptide Cat. No.: PE-04ACI99
Antibody Immunogen Sequence: YSP(pY)DML(bA)C
Antibody Immunogen Description: Corresponds to amino acid residues Y235 to L241; In the third Annexin domain. The second major in vivo phosphoryation site in Annexin A2.
Production Method: Corresponds to amino acid residues Y235 to L241; In the third Annexin domain. The second major in vivo phosphoryation site in Annexin A2.
Antibody Modification: Annexin phosphosite-specific antibody
Antibody Concentration: 0.5 mg/ml
Storage Buffer: Phosphate buffered saline pH 7.4, 0.05% Thimerasol
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Antibody microarray
Antibody Dilution Recommended: 2 µg/ml for immunoblotting
Antibody Potency: Very strong immunoreactivity with immunogen peptide on dot blots.
Antibody Species Reactivity: Human
Antibody Positive Control: The observed molecular mass of the processed target protein on SDS-PAGE gels is reported to be around 35-40 kDa.
Antibody Specificity: Very high
Antibody Cross Reactivity: No cross-reactive proteins detected in HeLa cells, Jurkat cells and in sea star oocytes.
Related Product 1: ANXA2-pY238 blocking peptide
Related Product 2: ANXA1-pY207 phosphosite-specific antibody (Cat. No.: AB-PN503)
Scientific Background: Annexin A2 is a calcium-regulated membrane-binding protein that binds two calcium ions with high affinity, which is greatly enhanced by anionic phospholipids. It may be involved in heat-stress response and inhibits PCSK9-enhanced LDL receptor degradation.
