Product Name:
MuSK-pY756
Product Number:
ab-pk872
Target Full Name: Muscle, skeletal receptor tyrosine protein kinase
Target Alias: Muscle specific tyrosine kinase receptor
Product Type Specific: Protein kinase phosphosite-specific antibody
Antibody Code: PK872
Antibody Target Type: Phosphosite-specific
Antibody Phosphosite: Y756
Protein UniProt: O15146
Protein SigNET: O15146
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Antibody Immunogen Source: Human MuSK sequence peptide Cat. No.: PE-04ABM80
Antibody Immunogen Sequence: SADY(pY)KAN(bA)C
Antibody Immunogen Description: Corresponds to amino acid residues S752 to N759; In protein kinase catalytic domain activation T-loop between subdomains VII and VIII.
Production Method: Corresponds to amino acid residues S752 to N759; In protein kinase catalytic domain activation T-loop between subdomains VII and VIII.
Antibody Modification: Protein kinase phosphosite-specific antibody
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH 7.4, 0.05% Thimerasol
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Antibody microarray
Antibody Dilution Recommended: 2 µg/ml for immunoblotting
Antibody Species Reactivity: Human
Antibody Positive Control: The observed molecular mass of the processed target protein on SDS-PAGE gels is reported to be around 100 kDa.
Related Product 1: MuSK-pY756 blocking peptide
Scientific Background: MuSK is a protein-tyrosine kinase of the TK group of protein kinases in the Musk family. This kinase is moderate to highly expressed in most tested human tissues except in the bladder, brain, pericardium, pituitary, spinal cord, trachea and vagina where it is notably low. MuSK is necessary for neuromuscular junction formation. Musk gene expression is highly regulated during neuromuscular junction and it is involved in intercellular communication present on the surface of cells that are activated by specific protein ligands. MuSK members play a key role in growth and differentiation of those cell types. Agrin signals through Musk to cluster acetylcholine receptors on the postsynaptic membrane of the neuromuscular junction. Musk interacts with Dok7, which may regulates its phosphotransferase activity. Dok7 is essential for MuSK activation in cultured myotubes. MuSK also plays a critical role in the development of normal blood vessels. Musk has been linked with the development of lung neuroendocrine carcinomas.
