Product Name:
SIK2-pS358
Product Number:
ab-pk813
Target Full Name: Salt-inducible serine/threonine-protein kinase SIK2; Serine-threonine-protein kinase SNF1-like kinase 2
Target Alias: DKFZp434K1115; KIAA0781; LOH11CR1I; Salt-inducible kinase 2; Salt-inducible serine/threonine kinase 2; SIK2; SN1L2; SNF1LK2
Product Type Specific: Protein kinase phosphosite-specific antibody
Antibody Code: PK813
Antibody Target Type: Phosphosite-specific
Antibody Phosphosite: S358
Protein UniProt: Q9H0K1
Protein SigNET: Q9H0K1
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Antibody Immunogen Source: Human SIK2 (QIK) sequence peptide Cat. No.: PE-04APE95
Antibody Immunogen Sequence: RRP(pS)TIA(bA)C
Antibody Immunogen Description: Corresponds to amino acid residues R355 to A361; After the kinase catalytic domain
Production Method: Corresponds to amino acid residues R355 to A361; After the kinase catalytic domain
Antibody Modification: Protein kinase phosphosite-specific antibody
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH 7.4, 0.05% Thimerasol
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Antibody microarray
Antibody Dilution Recommended: 2 µg/ml for immunoblotting
Antibody Potency: Medium immunoreactivity with immunogen peptide on dot blots.
Antibody Species Reactivity: Human
Antibody Positive Control: The observed molecular mass of the processed target protein on SDS-PAGE gels is reported to be around 100-150 kDa.
Antibody Specificity: Very high
Antibody Cross Reactivity: Almost no significant cross-reactivities detected in HeLa, MCF7 and T98G cells, but strong cross-reactivity with 75 kDa protein in sea star oocytes.
Related Product 1: SIK2-pS358 blocking peptide
Related Product 2: SIK2-1 pan-specific antibody (Cat. No.: AB-NK249-1)
Related Product 3: SIK2-2 pan-specific antibody (Cat. No.: AB-NK249-2)
Related Product 4: SIK2-3 pan-specific antibody (Cat. No.: AB-NK249-3)
Scientific Background: SIK2 (QIK) is a protein-serine/threonine kinase of the CAMK group and CAMKL family. It is a member of the salt-inducible kinase family. SIK2 may modulate the efficiency of insulin signal transduction, and affect insulin resistancy. It is activated by phosphorylation on T175 by LKB1 (STK11) in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39. It stimulates histone deacetylases export. SIK2 is a centrosome kinase required for bipolar mitotic spindle formation, and may be a potential target for therapy in ovarian cancer.
