Product Name:
RIPK2-pY381
Product Number:
ab-pk797
Target Full Name: Receptor-interacting serine/threonine-protein kinase 2 (RIPK2)
Target Alias: CARD3; CARD-containing IL-1 beta ICE-kinase; CARD-containing interleukin-1 beta converting enzyme associated kinase; CARD-containing interleukin-1 beta-converting enzyme-associated kinase; CARDIAK; GIG30; Kinase RIPK2; Receptor-interacting protein 2; Receptor-interacting serine/threonine protein kinase 2; RICK; RIP2; RIP-like-interacting CLARP kinase
Product Type Specific: Protein kinase phosphosite-specific antibody
Antibody Code: PK797
Antibody Target Type: Phosphosite-specific
Antibody Phosphosite: Y381
Protein UniProt: O43353
Protein SigNET: O43353
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Antibody Immunogen Source: Human RIPK2 (RIP2, RICK) sequence peptide Cat. No.: PE-04APJ90
Antibody Immunogen Sequence: QDA(pY)FMK(bA)C
Antibody Immunogen Description: Corresponds to amino acid residues Q378 to K384; In the region between the kinase catalytic and RHIM domains. This is a major in vivo phosphorylation site in RIPK2.
Production Method: Corresponds to amino acid residues Q378 to K384; In the region between the kinase catalytic and RHIM domains. This is a major in vivo phosphorylation site in RIPK2.
Antibody Modification: Protein kinase phosphosite-specific antibody
Antibody Concentration: 0.75 mg/ml
Storage Buffer: Phosphate buffered saline pH 7.4, 0.05% Thimerasol
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Antibody microarray
Antibody Dilution Recommended: 2 µg/ml for immunoblotting
Antibody Potency: Medium immunoreactivity with immunogen peptide on dot blots.
Antibody Species Reactivity: Human
Antibody Positive Control: The observed molecular mass of the processed target protein on SDS-PAGE gels is reported to be around 55-70 kDa.
Antibody Specificity: Very high
Related Product 1: RIPK2-pY381 blocking peptide
Related Product 2: RIPK2-pS176 phosphosite-specific antibody (Cat. No.: AB-PK796)
Scientific Background: RIPK2 (CARD3) is a protein-serine/threonine kinase of the TKL group and RIPK family. It plays an essential role in modulation of innate and adaptive immune responses. It Is activated by phosphorylation at S176.
