Product Name:
PIP5K-pS307
Product Number:
ab-pk762
Target Full Name: 1-phosphatidylinositol-3-phosphate 5-kinase
Target Alias: 1- phosphatidylinositol-4-phosphate 5-kinase; EC 2.7.1.68; FYV1; FYVE finger-containing phosphoinositide kinase; FYVE finger-containing PI kinase; KIAA0981; Kiaa0981; MGC40423; P235; Phosphoinositide kinase, FYVE finger containing; PIKfyve; PIP5K3; PtdIns(4)P-5- kinase; PtdIns(4)P-5-kinase
Product Type Specific: Protein kinase phosphosite-specific antibody
Antibody Code: PK762
Antibody Target Type: Phosphosite-specific
Antibody Phosphosite: S307
Protein UniProt: Q9Y2I7
Protein SigNET: Q9Y2I7
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Antibody Immunogen Source: Human PIP5K sequence peptide Cat. No.: PE-04AOO99
Antibody Immunogen Sequence: RSA(pS)ITN(bA)C
Antibody Immunogen Description: Corresponds to amino acid residues R304 to N310; In the region between the FYVE and DEP domains in the N-terminal part of the kinase.
Production Method: Corresponds to amino acid residues R304 to N310; In the region between the FYVE and DEP domains in the N-terminal part of the kinase.
Antibody Modification: Protein kinase phosphosite-specific antibody
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH 7.4, 0.05% Thimerasol
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Antibody microarray
Antibody Dilution Recommended: 2 µg/ml for immunoblotting
Antibody Potency: Very strong immunoreactivity with immunogen peptide on dot blots.
Antibody Species Reactivity: Human
Antibody Positive Control: The observed molecular mass of the processed target protein on SDS-PAGE gels is reported to be around 230-275 kDa.
Related Product 1: PIP5K-pS307 blocking peptide
Scientific Background: PIP5K (PIKFYVE) is a protein-serine/threonine kinase of the Atypical group. It regulates the production and degradation of phosphatidylinositol 3,5-bisphosphate. The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). It catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. It is required for endocytic-vacuolar pathway and nuclear migration, and plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes.
