Product Name:
PCTK2-pS180
Product Number:
ab-pk756
Target Full Name: Cell division protein kinase 17; Protein-serine kinase PCTAIRE-2
Target Alias: CDK17; KPT2; PCTAIRE protein kinase 2; PCTAIRE-motif protein kinase 2; PCTK2; Serine/threonine-protein kinase PCTAIRE-2
Product Type Specific: Protein kinase phosphosite-specific antibody
Antibody Code: PK756
Antibody Target Type: Phosphosite-specific
Antibody Phosphosite: S180
Protein UniProt: Q00537
Protein SigNET: Q00537
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Antibody Immunogen Source: Human PCTK2 (PCTAIRE2, CDK17)) sequence peptide Cat. No.: PE-04AJM99
Antibody Immunogen Sequence: RRA(pS)LSE(bA)C
Antibody Immunogen Description: Corresponds to amino acid residues R177 to E183; Just before kinase catalytic domain. One of two major sites of phosphorylation of PCTK2.
Production Method: Corresponds to amino acid residues R177 to E183; Just before kinase catalytic domain. One of two major sites of phosphorylation of PCTK2.
Antibody Modification: Protein kinase phosphosite-specific antibody
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH 7.4, 0.05% Thimerasol
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Antibody microarray
Antibody Dilution Recommended: 2 µg/ml for immunoblotting
Antibody Potency: Very strong immunoreactivity with immunogen peptide on dot blots.
Antibody Species Reactivity: Human
Antibody Positive Control: The observed molecular mass of the processed target protein on SDS-PAGE gels is reported to be around 55-65 kDa.
Antibody Specificity: Very high
Related Product 1: PCTK2-pS180 blocking peptide
Related Product 2: PCTK2-ANT pan-specific antibody (Cat. No.: AB-NK285-1)
Scientific Background: PCTK2 (PCTAIRE2, CDK17) is a protein-serine/threonine kinase of the CMGC group and CDK family. It functions in terminally differentiated neurons. It is also identified to be associated with circulating phospholipid and sphingolipid concentrations. This kinase likely phosphorylates histone H1. Insertional mutagenesis studies in mice support a role for PCTK2 in mouse cancer oncogenesis.