Product Name:
MOK-pT159+pY161
Product Number:
ab-pk720
Target Full Name: MAPK-MAK-MRK overlapping kinase; MOK protein kinase
Target Alias: RAGE; RAGE1
Product Type Specific: Protein kinase phosphosite-specific antibody
Antibody Code: PK720
Antibody Target Type: Phosphosite-specific
Antibody Phosphosite: T159+Y161
Protein UniProt: Q9UQ07
Protein SigNET: Q9UQ07
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Antibody Immunogen Source: Human MOK (RAGE) sequence peptide Cat. No.: PE-04ABB90
Antibody Immunogen Sequence: QPY(pT)E(pY)IS(bA)C
Antibody Immunogen Description: Corresponds to amino acid residues Q156 to S163; In protein kinase catalytic domain activation T-loop between subdomains VII and VIII.
Production Method: Corresponds to amino acid residues Q156 to S163; In protein kinase catalytic domain activation T-loop between subdomains VII and VIII.
Antibody Modification: Protein kinase phosphosite-specific antibody
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH 7.4, 0.05% Thimerasol
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Antibody microarray
Antibody Dilution Recommended: 2 µg/ml for immunoblotting
Antibody Potency: Medium immunoreactivity with immunogen peptide on dot blots.
Antibody Species Reactivity: Human
Antibody Positive Control: The observed molecular mass of the processed target protein on SDS-PAGE gels is reported to be around 47-52 kDa.
Related Product 1: MOK-pT159+pY161 blocking peptide
Related Product 2: MOK-AKCD pan-specific antibody (Cat. No.: AB-NK281-1)
Related Product 3: MOK-pY167 phosphosite-specific antibody (Cat. No.: AB-PK721)
Scientific Background: MOK is a protein-serine/threonine kinase of the CMGC group and RCK family. Phosphorylation appears to increase its enzymatic activity. MOK belongs to the MAP kinase superfamily, and it may phosphorylate exogenous substrates or autophosphorylate. The protein may functions in regulation of cillium length and intraflagellar transport in renal epithelial cells. MOK may be a tumour requiring protein (TRP), since it displays extremely low rates of mutation in human cancers. MOK is a renal tumour antigen that is silent in most normal tissues except for retina and a number of tumour cell types.
