Product Name:
MERTK-pY753
Product Number:
ab-pk704
Target Full Name: Tyrosine-protein kinase Mer; Proto-oncogene tyrosine-protein kinase MER
Target Alias: C-mer; C-mer proto-oncogene tyrosine kinase; Kinase Mer; MERK; MERTK; MGC133349Proto-oncogene tyrosine-protein kinase MER precursor; Receptor tyrosine kinase MerTK; RP38; MGC133349; CCDS2094.1; ENSG00000153208
Product Type Specific: Protein kinase phosphosite-specific antibody
Antibody Code: PK704
Antibody Target Type: Phosphosite-specific
Antibody Phosphosite: Y753
Protein UniProt: Q12866
Protein SigNET: Q12866
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Antibody Immunogen Source: Human MERTK (MER) sequence peptide Cat. No.: PE-04ANZ95
Antibody Immunogen Sequence: SGD(pY)YRQG(bA)C
Antibody Immunogen Description: Corresponds to amino acid residues S750 to G757; In protein kinase catalytic domain activation T-loop between subdomains VII and VIII.
Production Method: Corresponds to amino acid residues S750 to G757; In protein kinase catalytic domain activation T-loop between subdomains VII and VIII.
Antibody Modification: Protein kinase phosphosite-specific antibody
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH 7.4, 0.05% Thimerasol
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Antibody microarray
Antibody Dilution Recommended: 2 µg/ml for immunoblotting
Antibody Species Reactivity: Human
Antibody Positive Control: The observed molecular mass of the processed target protein on SDS-PAGE gels is reported to be around 105-115 kDa.
Related Product 1: MERTK-pY753 blocking peptide
Related Product 2: MERTK-pY749 phosphosite-specific antibody (Cat. No.: AB-PK702)
Related Product 3: MERTK-pY749+pY753 phosphosite-specific antibody (Cat. No.: AB-PK703)
Related Product 4: MerSubtide - Mer (MERTK) protein kinase substrate peptide
Scientific Background: MERTK (MER) is a protein-tyrosine kinase of the TK group and Axl family. It is a receptor kinase that functions in the regulation of cell survival, angiogenesis, migration and invasion, differentiation, and phagocytosis of apoptotic cells. Phosphorylation of Y749, Y753 and Y754 increases phosphotransferase activity.
