Product Name:
MARK3-pT507
Product Number:
ab-pk697
Target Full Name: MAP/microtubule affinity-regulating protein-serine kinase 3
Target Alias: Cdc25C- associated protein kinase 1; Cdc25C-associated protein kinase 1; CTAK1; C-TAK1; ELKL motif kinase 2; KP78; PAR1A; Protein kinase STK10; Ser/Thr protein kinase PAR-1; Serine/threonine protein kinase p78; Serine/threonine-protein kinase p78
Product Type Specific: Protein kinase phosphosite-specific antibody
Antibody Code: PK697
Antibody Target Type: Phosphosite-specific
Antibody Phosphosite: T507
Protein UniProt: P27448
Protein SigNET: P27448
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Antibody Immunogen Source: Human MARK3 sequence peptide Cat. No.: PE-04ANR99
Antibody Immunogen Sequence: RRN(pT)YVC(bA)C
Antibody Immunogen Description: Corresponds to amino acid residues R504 to C510; In the C-terminal quarter of the protein kinase. This is the major in vivo phosphorylation site in MARK3.
Production Method: Corresponds to amino acid residues R504 to C510; In the C-terminal quarter of the protein kinase. This is the major in vivo phosphorylation site in MARK3.
Antibody Modification: Protein kinase phosphosite-specific antibody
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH 7.4, 0.05% Thimerasol
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Antibody microarray
Antibody Dilution Recommended: 2 µg/ml for immunoblotting
Antibody Potency: Very strong immunoreactivity with immunogen peptide on dot blots.
Antibody Species Reactivity: Human
Antibody Positive Control: The observed molecular mass of the processed target protein on SDS-PAGE gels is reported to be around 80-85 kDa.
Related Product 1: MARK3-pT507 blocking peptide
Related Product 2: MARK1-ANT pan-specific antibody (Cat. No.: AB-NK098-2)
Related Product 3: MARK1-pT215 phosphosite-specific antibody (Cat. No.: AB-PK694)
Related Product 4: MARK1-pT215 phosphosite-specific antibody (Cat. No.: AB-PK695)
Related Product 5: MARK2-ANT pan-specific antibody (Cat. No.: AB-NK275-1)
Related Product 6: MARK2-BCT pan-specific antibody (Cat. No.: AB-NK275-2)
Related Product 7: MARK3-ANT pan-specific antibody (Cat. No.: AB-NK276-1)
Related Product 8: MARK3-BCT pan-specific antibody (Cat. No.: AB-NK276-2)
Related Product 9: MARK4-ANT pan-specific antibody (Cat. No.: AB-NK277-1)
Related Product 10: MARK4-NT pan-specific antibody (Cat. No.: AB-NK277-2)
Scientific Background: MARK3 is a protein-serine/threonine kinase of the CAMK group and CAMKL family. It has been linked to the specific phosphorylation of microtubule-associated proteins. Phosphorylation of T234 and S238 increases phosphotransferase activity. T211A substitution is involved in decreased phosphorylation and activation by LKB1/LKB1 complex. Phosphorylation of T95 and S96 inhibits phosphotransferase activity.
