Product Name:
Ltk-pY672
Product Number:
ab-pk687
Target Full Name: Leukocyte tyrosine kinase receptor
Target Alias: Protein tyrosine kinase-1; TYK1; CCDS10077.1; ENSG00000062524
Product Type Specific: Protein kinase phosphosite-specific antibody
Antibody Code: PK687
Antibody Target Type: Phosphosite-specific
Antibody Phosphosite: Y672
Protein UniProt: P29376
Protein SigNET: P29376
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Antibody Immunogen Source: Human Ltk sequence peptide Cat. No.: PE-04ANO95
Antibody Immunogen Sequence: RDI(pY)RAS(bA)C
Antibody Immunogen Description: Corresponds to amino acid residues R669 to S675; In protein kinase catalytic domain activation T-loop between subdomains VII and VIII. This is the major in vivo phosphorylation site in Ltk.
Production Method: Corresponds to amino acid residues R669 to S675; In protein kinase catalytic domain activation T-loop between subdomains VII and VIII. This is the major in vivo phosphorylation site in Ltk.
Antibody Modification: Protein kinase phosphosite-specific antibody
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH 7.4, 0.05% Thimerasol
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Antibody microarray
Antibody Dilution Recommended: 2 µg/ml for immunoblotting
Antibody Potency: Very strong immunoreactivity with immunogen peptide on dot blots.
Antibody Species Reactivity: Human
Antibody Positive Control: The observed molecular mass of the processed target protein on SDS-PAGE gels is reported to be around 85-95 kDa.
Related Product 1: Ltk-pY672 blocking peptide
Scientific Background: Ltk is a receptor protein-tyrosine kinase of the TK group and Alk family. The exact function of this protein is not known. However, studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival via activation of the PI3 kinase pathway. It is involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport.
