Product Name:
LMR2-pS1450
Product Number:
ab-pk684
Target Full Name: Serine/threonine-protein kinase LMTK2
Target Alias: LMTK2; 2900041G10Rik; AATYK2; BREK; CDK5,p35-regulated kinase; Cprk; KIAA1079; Kinase LMR2; Kinase phosphatase inhibitor 2
Product Type Specific: Protein kinase phosphosite-specific antibody
Antibody Code: PK684
Antibody Target Type: Phosphosite-specific
Antibody Phosphosite: S1450
Protein UniProt: Q8IWU2
Protein SigNET: Q8IWU2
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Antibody Immunogen Source: Human LMR2 sequence peptide Cat. No.: PE-04ANL95
Antibody Immunogen Sequence: KYF(pS)PPP(bA)C
Antibody Immunogen Description: Corresponds to amino acid residues K1447 to P1453; Near the C-terminus of the protein kinase.
Production Method: Corresponds to amino acid residues K1447 to P1453; Near the C-terminus of the protein kinase.
Antibody Modification: Protein kinase phosphosite-specific antibody
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH 7.4, 0.05% Thimerasol
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Antibody microarray
Antibody Dilution Recommended: 2 µg/ml for immunoblotting
Antibody Potency: Very strong immunoreactivity with immunogen peptide on dot blots.
Antibody Species Reactivity: Human
Antibody Positive Control: The observed molecular mass of the processed target protein on SDS-PAGE gels is reported to be around 150-175 kDa.
Antibody Specificity: Very high
Antibody Cross Reactivity: No significant cross-reactive proteins detected in HeLa and T98G cells, except for a weak cross-reactive protein of ~75 kDa in FBS-treated HeLa cells..
Related Product 1: LMR2-pS1450 blocking peptide
Scientific Background: LMR2 (LMTK2) is a protein-tyrosine kinase of the TK group and Lmr family. It is a receptor kinase that may have an essential role in spermatogenesis. In a large 2-stage genomewide association study of prostate cancer, SNP in intron of the LMR gene is associated susceptibility to prostate cancer. It has been shown to phosphorylate PPP1C, phosphorylase b and CFTR.
