Product Name:
CDK11A-pT583
Product Number:
ab-pk567
Target Full Name: Cell division cycle 2-like 2 protein kinase
Target Alias: CDK19; CD2L6; CDC2L6; CDK8-like; CDK8-like cyclin-dependent kinase; CDK8-like cyclin-dependent kinase 11; Cell division cycle 2-like 6; Cyclin-dependent kinase (CDC2-like) 11; Death-preventing kinase; KIAA1028; CDC2L1; CDK11A; CDK11-p110; CDK11-p46; CDK11-p58; CLK-1; FLJ59152; p58; p58CDC2L1; p58CLK-1; PITSLRE; PK58; Q9UQ88; A4VCI5; Q5QPQ9; Q6P5Y5
Product Type Specific: Protein kinase phosphosite-specific antibody
Antibody Code: PK565
Antibody Target Type: Phosphosite-specific
Antibody Phosphosite: T583
Protein UniProt: Q9UQ88
Protein SigNET: Q9UQ88
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Antibody Immunogen Source: Human CDK11A (Cdc2L2; PITSLRE) sequence peptide Cat. No.: PE-04AJJ95
Antibody Immunogen Sequence: KAY(pT)PVV(bA)C
Antibody Immunogen Description: Corresponds to amino acid residues K580 to V586; In protein kinase catalytic domain activation T-loop between subdomains VII and VIII.
Production Method: Corresponds to amino acid residues K580 to V586; In protein kinase catalytic domain activation T-loop between subdomains VII and VIII.
Antibody Modification: Protein kinase phosphosite-specific antibody
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH 7.4, 0.05% Thimerasol
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Antibody microarray
Antibody Dilution Recommended: 2 µg/ml for immunoblotting
Antibody Potency: Medium immunoreactivity of a target-sized protein by Western blotting in sea star oocytes and weaker in Jurkat cells. Strong immunoreactivity with immunogen peptide on dot blots.
Antibody Species Reactivity: Human
Antibody Positive Control: The observed molecular mass of the processed target protein on SDS-PAGE gels is reported to be around 90-100 kDa.
Antibody Specificity: High-very high
Antibody Cross Reactivity: No significant cross-reactivities detected in Jurkat, Hela, Jurkat and MCF7 cells, but insulin increases 75 kDa in MCF7 cells
Related Product 1: CDK11A-pT583 blocking peptide
Related Product 2: RNA polymerase II-CT KinSub - heptapeptide repeat from C-terminus peptide; CDKtide protein kinase substrate peptide
Scientific Background: CDK11 (CDK19, CD2L6; PITSLRE) is a protein-serine/threonine kinase of the CMGC group and CDK family. It is a protein kinase that is a component of Mediator coactivator complex, which is required for transcriptional activation. It has cyclin-dependent protein serine/threonine kinase activity. RT-PCR ELISA detected highest expression was in corpus callosum, followed by kidney and ovary.
