Product Name:
BMPR2-pS375
Product Number:
ab-pk545
Target Full Name: Bone morphogenetic protein receptor type-2
Target Alias: BMP type II receptor; BMPR3; BMPR-II; BMR2; Bone morphogenetic protein receptor type II precursor; Bone morphogenetic protein receptor, type II; BRK-3; PPH1; T-ALK
Product Type Specific: Protein kinase phosphosite-specific antibody
Antibody Code: PK544
Antibody Target Type: Phosphosite-specific
Antibody Phosphosite: S375
Protein UniProt: Q13873
Protein SigNET: Q13873
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Antibody Immunogen Source: Human BMPR2 sequence peptide Cat. No.: PE-04AIS99
Antibody Immunogen Sequence: AAI(pS)EVG(bA)C
Antibody Immunogen Description: Corresponds to amino acid residues A372 to G378; In the protein kinase catalytic domain activation T loop region between subdomains VII and VIII.
Production Method: Corresponds to amino acid residues A372 to G378; In the protein kinase catalytic domain activation T loop region between subdomains VII and VIII.
Antibody Modification: Protein kinase phosphosite-specific antibody
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH 7.4, 0.05% Thimerasol
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Antibody microarray
Antibody Dilution Recommended: 2 µg/ml for immunoblotting
Antibody Species Reactivity: Human
Antibody Positive Control: The observed molecular mass of the processed target protein on SDS-PAGE gels is reported to be around 120-130 kDa.
Related Product 1: BMPR2-pS375 blocking peptide
Scientific Background: BMPR2 (bone morphogenetic protein receptor type II) is a protein-serine/threonine kinase of the TKL group and STKR family. It is a transmembrane receptor kinase that is a member of the bone morphogenetic protein (BMP) receptor family. BMPR2 functions to bind BMPs, which are named for their role in endochondral bone formation and embryogenesis. Activated by binding bone morphogenetic protein. This type II receptor phosphorylates and activates type I receptors which autophosphorylate, then phosphorylate SMAD transcriptional regulators. Insertional mutagenesis studies in mice support a role for this protein kinase in mouse cancer oncogenesis.
