Product Name:
ANKRD3-pS438
Product Number:
ab-pk524
Target Full Name: Ankyrin repeat domain protein-serine kinase 3 (RIPK4, DIK)
Target Alias: ANKK2; Ankyrin repeat domain protein 3; DIK; Kinase ANKRD3; PKC-delta-interacting protein kinase; PKC-regulated kinase PKK; Receptor-interacting serine-threonine kinase 4; RIP4; RIPK4; DIK
Product Type Specific: Protein kinase phosphosite-specific antibody
Antibody Code: PK523
Antibody Target Type: Phosphosite-specific
Antibody Phosphosite: S438
Protein UniProt: P57078
Protein SigNET: P57078
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Antibody Immunogen Source: Human ANKRD3 sequence peptide Cat. No.: PE-04AIH99
Antibody Immunogen Sequence: LSL(pS)FER(bA)C
Antibody Immunogen Description: Corresponds to amino acid residues L435 to R441; In the region between the kinase catalytic and Ank_2 domains.The major site of phosphorylation in ANKRD3.
Production Method: Corresponds to amino acid residues L435 to R441; In the region between the kinase catalytic and Ank_2 domains.The major site of phosphorylation in ANKRD3.
Antibody Modification: Protein kinase phosphosite-specific antibody
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH 7.4, 0.05% Thimerasol
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Antibody microarray
Antibody Dilution Recommended: 2 µg/ml for immunoblotting
Antibody Potency: Very strong immunoreactivity with immunogen peptide on dot blots.
Antibody Species Reactivity: Human
Antibody Positive Control: The observed molecular mass of the processed target protein on SDS-PAGE gels is reported to be around 90-100 kDa.
Antibody Specificity: Very high
Antibody Cross Reactivity: No cross-reactive proteins detected in A431 cells, HeLa cells, and sea star oocytes.
Related Product 1: ANKRD3-pS438 blocking peptide
Scientific Background: ANKRD3 (RIPK4) is a protein-serine/threonine kinase of the TKL group and RIPK family. Phosphorylation at T184 increases the phosphotransferase activity. Insertional mutagenesis studies in mice support a role for this protein kinase in mouse cancer oncogenesis.
