Product Name:
A6r-pY309
Product Number:
ab-pk503
Target Full Name: Twinfilin, actin-binding protein, 2; Protein tyrosine kinase 9-like
Target Alias: TWF2; PTK9L
Product Type Specific: Protein kinase phosphosite-specific antibody
Antibody Code: PK502
Antibody Target Type: Phosphosite-specific
Antibody Phosphosite: Y309
Protein UniProt: Q6IBS0
Protein SigNET: Q6IBS0
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Antibody Immunogen Source: Human A6r (Twinfin-2) sequence peptide Cat. No.: PE-04ACE99
Antibody Immunogen Sequence: EFL(pY)DEV(bA)C
Antibody Immunogen Description: Corresponds to amino acid residues E306 to V312; In the end of the Cofilin_ADF domain. The major site of phosphorylation of A6r.
Production Method: Corresponds to amino acid residues E306 to V312; In the end of the Cofilin_ADF domain. The major site of phosphorylation of A6r.
Antibody Modification: Protein kinase phosphosite-specific antibody
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH 7.4, 0.05% Thimerasol
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Antibody microarray
Antibody Dilution Recommended: 2 µg/ml for immunoblotting
Antibody Potency: Medium immunoreactivity with immunogen peptide on dot blots.
Antibody Species Reactivity: Human
Antibody Positive Control: The observed molecular mass of the processed target protein on SDS-PAGE gels is reported to be around 39-40 kDa.
Antibody Cross Reactivity: No significant cross-reactive proteins detected in seastar oocytes.
Related Product 1: A6r-pY309 blocking peptide
Related Product 2: A6-pY309 phosphosite-specific antibody (Cat. No.: AB-PK501)
Scientific Background: A6r appears to be an actin-binding protein involved in motile and morphological processes. It inhibits actin polymerization, probably by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. It seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles.
