Product Name:
SHIP2-2
Product Number:
ab-np045-1
Target Full Name: Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2
Target Alias: 51C protein; Inositol polyphosphate 5-phosphatase; Inositol polyphosphate phosphatase-like 1; SH2-containing inositol 5-phosphatase 2; SHIP2
Product Type Specific: SHIP2 (INPPL1) pan-specific antibody
Antibody Code: NP045-2
Antibody Target Type: Pan-specific
Protein UniProt: O15357
Protein SigNET: O15357
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Antibody Immunogen Source: Human SHIP2 (INPPL1) sequence peptide Cat. No.: PE-01BBT99
Antibody Immunogen Sequence: CRRLHSEVDKVLSGLE
Antibody Immunogen Description: Corresponds to amino acid residues C215 to E230
Production Method: Corresponds to amino acid residues C215 to E230
Antibody Modification: SHIP2 (INPPL1) pan-specific antibody
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH 7.4, 0.05% Thimerasol
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Antibody microarray
Antibody Dilution Recommended: 1 µg/ml for immunoblotting
Antibody Species Reactivity: Human; Mouse
Antibody Positive Control: The observed molecular mass of the processed target protein on SDS-PAGE gels is reported to be around 130-160 kDa.
Related Product 1: SHIP2-2 blocking peptide
Related Product 2: SHIP2-1 pan-specific antibody (Cat. No.: AB-NP045-1)
Related Product 3: SHIP2-3 pan-specific antibody (Cat. No.: AB-NP045-3)
Related Product 4: SHIP2-pY886 phosphosite-specific antibody (Cat. No.: AB-PN534)
Scientific Background: SHIP2 (INPPL1) is a phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, and negatively regulate the PI3K (phosphoinositide 3-kinase) pathways. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signalling or GLUT4 trafficking. It confers resistance to dietary obesity. It may also hydrolyze PtdIns(1,3,4,5)P4.