Product Name:
SHIP1-3
Product Number:
ab-np044-2
Target Full Name: Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1
Target Alias: Inositol polyphosphate-5-phosphatase of 145 kDa; Inositol polyphosphate-5-phosphatase, 145kDa; INPP5D; P150Ship; Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1; SH2-containing inositol 5'-phosphatase 1; SHIP1; SHIP-1; SIP-145
Product Type Specific: SHIP1 (INPP5D) pan-specific antibody
Antibody Code: NP044-3
Antibody Target Type: Pan-specific
Protein UniProt: Q92835
Protein SigNET: Q92835
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Antibody Immunogen Source: Human SHIP1 (INPP5D) sequence peptide Cat. No.: PE-01BBR99
Antibody Immunogen Sequence: CGRDYRDNTELPHHGK
Antibody Immunogen Description: Corresponds to amino acid residues R1159 to K1172
Production Method: Corresponds to amino acid residues R1159 to K1172
Antibody Modification: SHIP1 (INPP5D) pan-specific antibody
Antibody Concentration: 0.5 mg/ml
Storage Buffer: Phosphate buffered saline pH 7.4, 0.05% Thimerasol
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Antibody microarray
Antibody Dilution Recommended: 1 µg/ml for immunoblotting
Antibody Species Reactivity: Human
Antibody Positive Control: The observed molecular mass of the processed target protein on SDS-PAGE gels is reported to be around 132-145 kDa.
Antibody Specificity: High
Related Product 1: SHIP1-3 blocking peptide
Related Product 2: SHIP1-1 pan-specific antibody (Cat. No.: AB-NP044-1)
Related Product 3: SHIP1-2 pan-specific antibody (Cat. No.: AB-NP044-2)
Related Product 4: http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN560
Scientific Background: SHIP1 (INPP5D) is a phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, to negatively regulate PI3K (phosphoinositide 3-kinase) pathways. It acts as a negative regulator of B-cell antigen receptor signalling, and mediates signalling from the FC-gamma-RIIB receptor (FCGR2B) as well as a negative regulator of myeloid cell proliferation/survival and chemotaxis, neutrophil migration, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signalling in platelets and JNK signalling in B-cells. It regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. It may also hydrolyze PtdIns(1,3,4,5)P4.