Product Name:
DUSP6-1
Product Number:
ab-np039-3
Target Full Name: Dual specificity protein phosphatase 6
Target Alias: Dual specificity phosphatase 6; Dual specificity protein phosphatase PYST1; DUS6; MAP kinase phosphatase 3; Mitogen-activated protein kinase phosphatase 3; MKP3; MKP-3; PYST1
Product Type Specific: Protein phosphatase pan-specific antibody
Antibody Code: NP040-1
Antibody Target Type: Pan-specific
Protein UniProt: Q16828
Protein SigNET: Q16828
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Antibody Immunogen Source: Human DUSP6 (MKP3) sequence peptide Cat. No.: PE-01BBA95
Antibody Immunogen Sequence: DTLRPVPFASEMAIC
Antibody Immunogen Description: Corresponds to amino acid residues D3 to I16; N-terminus
Production Method: Corresponds to amino acid residues D3 to I16; N-terminus
Antibody Modification: Protein phosphatase pan-specific antibody
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH 7.4, 0.05% Thimerasol
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Antibody microarray
Antibody Dilution Recommended: 1 µg/ml for immunoblotting
Antibody Species Reactivity: Human; Mouse
Antibody Positive Control: The observed molecular mass of the processed target protein on SDS-PAGE gels is reported to be around 35-45 kDa.
Antibody Specificity: Medium
Related Product 1: DUSP6-1 blocking peptide
Related Product 2: DUSP6-2 pan-specific antibody (Cat. No.: AB-NP040-2)
Related Product 3: DUSP6-3 pan-specific antibody (Cat. No.: AB-NP040-3)
Scientific Background: DUSP6 (MKP3) is a dual specificity phosphatase that dephosphorylates MAP kinase ERK1 (and ERK2) on both 'T202' and 'Y204', and inhibits its activity during mitosis following initial growth factor activation.