Product Name:
DUSP4-3
Product Number:
ab-np007-3
Target Full Name: Dual specificity protein phosphatase 4
Target Alias: Dual specificity protein phosphatase hVH2; DUS4; DUSP4; MAP kinase phosphatase-2; Mitogen-activated protein kinase phosphatase-2; MKP2; VH2; VH2/TYP1
Product Type Specific: Protein phosphatase pan-specific antibody
Antibody Code: NP007-4
Antibody Target Type: Pan-specific
Protein UniProt: Q13115
Protein SigNET: Q13115
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Antibody Immunogen Source: Human DUSP4 (MKP2) sequence peptide Cat. No.: PE-01BAW85
Antibody Immunogen Sequence: CSWFMEAIEYIDAVKD
Antibody Immunogen Description: Corresponds to amino acid residues S257 to D271
Production Method: Corresponds to amino acid residues S257 to D271
Antibody Modification: Protein phosphatase pan-specific antibody
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH 7.4, 0.05% Thimerasol
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Antibody microarray
Antibody Dilution Recommended: 2 µg/ml for immunoblotting
Antibody Species Reactivity: Human; Mouse
Antibody Positive Control: The observed molecular mass of the processed target protein on SDS-PAGE gels is reported to be around 35-40 kDa.
Antibody Specificity: High
Related Product 1: DUSP4-3 blocking peptide
Related Product 2: DUSP4-1 pan-specific antibody (Cat. No.: AB-NP007-2)
Related Product 3: DUSP4-2 pan-specific antibody (Cat. No.: AB-NP007-3)
Scientific Background: DUSP4 (MKP2, VH2) is a dual specificity phosphatase that dephosphorylates MAP kinase ERK2 (and ERK1) on both 'T183' and 'Y185', and inhibits its activity during mitosis following initial growth factor activation.