Product Name:
TARP3-Pan (CACNG3)
Product Number:
ab-nn456
Target Full Name: Voltage-dependent calcium channel gamma-3 subunit
Target Alias: CCG3; Neuronal voltage-gated calcium channel gamma-3 subunit
Product Type Specific: CACNG3 pan-specific antibody
Antibody Code: NN456
Antibody Target Type: Pan-specific
Protein UniProt: O60359
Protein SigNET: TARP3
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Antibody Immunogen Source: Synthetic peptide patterned after human TARP3
Antibody Immunogen Sequence: CQFHNSTPKEFKESLHNNP
Antibody Immunogen Description: Corresponds to amino acid residues Q290 to P307.
Production Method: The immunizing peptide was produced by solid phase synthesis on a multipep peptide synthesizer and purified by reverse-phase hplc chromatography. Purity was assessed by analytical hplc and the amino acid sequence confirmed by mass spectrometry analysis. This peptide was coupled to KLH prior to immunization into rabbits. New Zealand White rabbits were subcutaneously injected with KLH-coupled immunizing peptide every 4 weeks for 4 months. The sera from these animals was applied onto an agarose column to which the immunogen peptide was thio-linked. Antibody was eluted from the column with 0.1 M glycine, pH 2.5. Subsequently, the antibody solution was neutralized to pH 7.0 with saturated Tris.
Antibody Modification: Unconjugated. Contact KInexus if you are interest in having the antibody biotinylated or coupled with fluorescent dyes.
Antibody Concentration: 1.0 mg/ml
Storage Buffer: Phosphate buffered saline pH 7.4, 0.05% Thimerasol
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Antibody microarray
Antibody Dilution Recommended: 2 µg/ml for immunoblotting
Antibody Species Reactivity: This antibody detects the target protein in the following species due to conservation of amino acid sequence: Human | Chimpanzee | Rhesus macaque | Dog | Rat | Mouse | Platypus | Chicken.
Related Product 1: TARP Gamma2/Stargazin pan-specific antibody (Cat. No.: AB-NN224-2)
Related Product 2: TARP Gamma2/4/8 (Stargazin) pan-specific antibody (Cat. No.: AB-NN224-1)
Scientific Background: TARP3 (CACNG3; Voltage-dependent calcium channel gamma-3 subunit) is a multi-pass membrane calcium channel protein that belongs to the PMP-22/EMP/MP20 family, CACNG subfamily. It regulates the trafficking to the somatodendritic compartment and gating properties of AMPA-selective glutamate receptors (AMPARs). It promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. It does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. It is thought to stabilize the calcium channel in an inactivated (closed) state. This description may include information annotated by UniProt and/or Google AI.