Product Name:
Synaptophysin
Product Number:
ab-nn370-1
Target Full Name: Major synaptic vesicle protein p38
Target Alias: Major synaptic vesicle protein p38; SYPH
Product Type Specific: Synaptic protein pan-specific antibody
Antibody Code: NN370-1
Antibody Target Type: Pan-specific
Protein UniProt: P08247
Protein SigNET: Synaptophysin
Antibody Host Species: Rabbit
Antibody Immunogen Source: Synthetic peptide patterned after after human Synaptophysin
Antibody Modification: Unconjugated. Contact KInexus if you are interest in having the antibody biotinylated or coupled with fluorescent dyes.
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Antibody Potency: In mouse brain lysates, this antibody detects a ~38 kDa protein by Western blotting.
Antibody Species Reactivity: This antibody detects the target protein in the following species due to conservation of amino acid sequence: Human.
Antibody Cross Reactivity: No other prominent cross-reactive proteins in mouse brain lysates.
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Scientific Background: SYP (Synaptophysin) is a 38 kDa integral, multi-pass membrane glycoprotein that belongs to the synaptophysin/synaptobrevin family. It features with four transmembrane domains and both N- and C-terminal tails located on the cytoplasmic surface of vesicles. It is possibly involved in structural functions as organizing other membrane components or in targeting tneuronal synaptic vesicle and neuroendocrine secretory granules to the plasma membrane. It is implicated in the regulation of short-term and long-term synaptic plasticity. It regulates vesicle endocytosis and binds to the SNARE protein synaptobrevin II. It is also involved in cholesterol binding. As a key regulator of synaptic vesicle endocytosis and trafficking, it constitutes about 7–10% of total vesicle protein. It is found in the brain, with expression in the hippocampus, the neuropil in the dentate gyrus, where expression is higher in the outer half of the molecular layer than in the inner half, and in the neuropil of CA4 and CA3 regions of the brain. Mutations are associated with X-linked intellectual disability. This description may include information annotated by UniProt and/or Google AI.