Product Name:
TrpC5
Product Number:
ab-nn350-1
Target Full Name: Short transient receptor potential channel 5
Target Alias: Htrp5; TRP5
Product Type Specific: TRPC5 calcium channel pan-specific antibody
Antibody Code: NN350-1
Antibody Target Type: Pan-specific
Protein UniProt: Q9UL62
Protein SigNET: TrpC5
Antibody Type: Monoclonal
Antibody Host Species: Mouse
Antibody Ig Isotype Clone: IgG2b
Antibody Immunogen Source: Synthetic peptide patterned after human TrpC5 (also known as short transient receptor potential channel 5, and Htrp5)
Antibody Immunogen Sequence: SKAESSSKRSFMGPSLKKL
Antibody Immunogen Description: Corresponds to amino acid residues S827-L845.
Production Method: Protein G purified
Antibody Modification: Unconjugated. Contact KInexus if you are interest in having the antibody biotinylated or coupled with fluorescent dyes.
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH7.4, 50% glycerol, 0.09% sodium azide
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Immunohistochemistry | Immunoprecipitation
Antibody Dilution Recommended: WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Antibody Potency: In mouse brain lysates, this antibody detects a ~110 kDa protein by Western blotting.
Antibody Species Reactivity: This antibody detects the target protein in the following species due to conservation of amino acid sequence: Human | Rat | Mouse.
Antibody Positive Control: 1 µg/ml of SMC-344 was sufficient for detection of TrpC5 in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Antibody Specificity: Very high
Related Product 1: TrpC7 pan-specific antibody (Cat. No.: AB-NN351-1)
Related Product 2: TrpM7 pan-specific antibody (Cat. No.: AB-NK305-1)
Related Product 3: TrpV3 pan-specific antibody (Cat. No.: AB-NN353-1)
Scientific Background: Transient receptor potential cation channel, subfamily C, member 5, also known as TRPC5, is a subtype of the TRPC family of mammalian transient receptor potential ion channels. Homo-multimeric TRPC5 and hetero-multimeric TRPC5-TRPC1 channels are activated by extracellular reduced thioredoxin (1). This activation probably plays a role in rheumatoid arthritis. It has also been recently found to be involved in the action on anaesthetics such as chloroform, halothane and propofol (2). This description may include information annotated by UniProt and/or Google AI.