Product Name:
Kir2.2
Product Number:
ab-nn278-1
Target Full Name: ATP-sensitive inward rectifier potassium channel 12
Target Alias: IRK2; KCNJ12; kcnj12x; KCNJN1; Kir2.2v; potassium inwardly rectifying channel subfamily J member 12
Product Type Specific: Potassium channel pan-specific antibody
Antibody Code: NN278-1
Antibody Target Type: Pan-specific
Protein UniProt: Q14500
Protein SigNET: Q14500
Antibody Type: Monoclonal
Antibody Host Species: Mouse
Antibody Ig Isotype Clone: IgG1
Antibody Immunogen Source: Fusion protein amino acids 362-427 of rat Kir2.2
Antibody Modification: Potassium channel pan-specific antibody
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH7.4, 50% glycerol, 0.09% sodium azide
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Immunohistochemistry | ICC/Immunofluorescence
Antibody Dilution Recommended: WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Antibody Potency: Medium potency. Detects a ~45 kDa protein in cell and tissue lysates by Western blotting.
Antibody Species Reactivity: Human | Mouse | Rat
Antibody Positive Control: 1 µg/ml of SMC-311 was sufficient for detection of Kir2.2 in 30 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Antibody Specificity: Very high
Antibody Cross Reactivity: No cross-reactivity against Kir2.2 or Kir2.3.
Related Product 1: Kir2.3 pan-specific antibody (Cat. No.: AB-NN279-1)
Scientific Background: The Kir2.1 inward-rectifier potassium ion channel is encoded by the KCNJ2 gene. A defect in this gene is associated with Andersen-Tawil syndrome (1).