Product Name:
GLUT2
Product Number:
ab-nn262-1
Target Full Name: Solute carrier family 2, facilitated glucose transporter member 2
Target Alias: Glucose Transporter 2; Glucose Transporter GLUT2; BLUT-2; GTR_Human; SLC2a2; Solute Carrier Family 2 (facilitated glucose transporter) member 2
Product Type Specific: Solute carrier protein pan-specific antibody
Antibody Code: NN262-1
Antibody Target Type: Pan-specific
Protein UniProt: P11168
Protein SigNET: GLUT2
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Antibody Ig Isotype Clone: N/A
Antibody Immunogen Source: Synthetic peptide patterned after the C-terminal of human GLUT2
Production Method: Peptide Affinity purified
Antibody Modification: Unconjugated. Contact KInexus if you are interest in having the antibody biotinylated or coupled with fluorescent dyes.
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline, 50% glycerol, 0.09% sodium azide
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting
Antibody Dilution Recommended: WB (1:1000); optimal dilutions for assays should be determined by the user.
Antibody Potency: Predicted molecular mass at ~57.5 kDa protein in cell and tissue lysates by Western blotting. Observed molecular masess at 60-70 kDa and 38-45 kDa.
Antibody Species Reactivity: This antibody detects the target protein in the following species due to conservation of amino acid sequence: Human | Rat .
Antibody Specificity: Very high
Antibody Cross Reactivity: One weak 50 kDa cross-reactive protein in mouse brain lysates.
Scientific Background: GLUT2 (Glucose Transporter 2) is a high-capacity, low-affinity transmembrane protein with 12 transmembrane segments.It belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. It is responsible for transporting glucose, fructose, and galactose across the plasma membranes of hepatocytes, pancreatic beta-islet cells, and the basolateral membranes of intestinal and kidney cells. It acts as a primary glucose sensor in the liver and pancreas, and plays a key role in postprandial glucose uptake and insulin secretion. GLUT2 operates via facilitated diffusion, i.e., it moves sugars down their concentration gradient without directly using ATP. It has a high Km (roughly 15–20 mM) with low affinity for glucose,which allows it to transport large amounts of glucose only when blood sugar levels are high. It is found in pancreatic beta-islet cells for sensing high blood glucose and triggering insulin release. In liver hepatocytes it facilitates uptake of glucose for glycogen synthesis or release of glucose during fasting. In intestines and kidney, it transports sugars across the basolateral membrane into the bloodstream. Unlike GLUT4, GLUT2 is not directly regulated by insulin for its presence on the plasma membrane in hepatocytes. Mutations in the SLC2A2 gene cause Fanconi-Bickel syndrome, a rare metabolic disorder characterized by hepatomegaly and renal dysfunction. This description may include information annotated by UniProt and/or Google AI.