Product Name:
GABARAPL1
Product Number:
ab-nn258-1
Target Full Name: Gamma-aminobutyric acid receptor-associated protein-like 1
Target Alias: APG8 like Antibdoy; ATG8; GABA(A) Receptor Associated Protein Like 1; Glandular epithelial cell protein 1
Product Type Specific: Autophagy protein pan-specific antibody
Antibody Code: NN258-1
Antibody Target Type: Pan-specific
Protein UniProt: Q9H0R8
Protein SigNET: GABARAPL1
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Antibody Ig Isotype Clone: N/A
Antibody Immunogen Source: Synthetic peptide patterned after the C-terminal of human GABARAPL1
Production Method: Peptide Affinity purified
Antibody Modification: Unconjugated. Contact KInexus if you are interest in having the antibody biotinylated or coupled with fluorescent dyes.
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline, 50% glycerol, 0.09% sodium azide
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting
Antibody Dilution Recommended: WB (1:1000); optimal dilutions for assays should be determined by the user.
Antibody Potency: In mouse brain lysates, this antibody detects a ~14-16 kDa protein by Western blotting.
Antibody Species Reactivity: This antibody detects the target protein in the following species due to conservation of amino acid sequence: Human | Rat .
Antibody Specificity: Medium
Antibody Cross Reactivity: Two very strong cross-reactive proteins of 55 and 37 kDa size and other minor cross-reactive proteins in mouse brain lysates.
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Scientific Background: GABARAPL1 (Gamma-aminobutyric acid receptor-associated protein-like 1) is a ubiquitous 14 kDa ubiquitin-like modifier of the ATG8 family. It functions to increase cell-surface expression of kappa-type opioid receptor by facilitating anterograde intracellular trafficking of the receptor. It is also involved in formation of autophagosomal vacuoles, lysosome fusion and intracellar trafficking. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Beyond autophagy, it helps transport receptors, such as the kappa-type opioid receptor, to the cell surface. It is expressed at very high levels in the brain, heart, peripheral blood leukocytes, liver, kidney, placenta and skeletal muscle, and very low levels in thymus and small intestine. In the brain, GABARAPL1 expression is particularly intense in motoneurons in the embryo and in neurons involved in somatomotor and neuroendocrine functions in the adult, particularly in the substantia nigra pars compacta. Its expression is frequently downregulated in cancer, and higher expression has been linked to better prognosis in certain breast cancers. GABARAPL1 acts to regulate cell proliferation.This description may include information annotated by UniProt and/or Google AI.