Product Name:
GABA-A Receptor Epsilon
Product Number:
ab-nn255-1
Target Full Name: Gamma-aminobutyric acid receptor subunit epsilon
Target Alias: Gamma-aminobutyric acid receptor epsilon subunit; GABRE
Product Type Specific: Chloride channel pan-specific antibody
Antibody Code: NN255-1
Antibody Target Type: Pan-specific
Protein UniProt: P78334
Protein SigNET: P78334
Antibody Type: Monoclonal
Antibody Host Species: Mouse
Antibody Ig Isotype Clone: IgG2A
Antibody Immunogen Source: Fusion protein amino acids 27-253 (Extracellular N-terminus) of human GABA-A Receptor Epsilon
Antibody Modification: Chloride channel pan-specific antibody
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH7.4, 50% glycerol, 0.1% sodium azide
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Immunohistochemistry | ICC/Immunofluorescence
Antibody Dilution Recommended: WB (1:1000); optimal dilutions for assays should be determined by the user.
Antibody Potency: In mouse brain lysates, this antibody detects a ~60 kDa protein by Western blotting.
Antibody Species Reactivity: Human | Rat
Antibody Positive Control: A 1:100 dilution of SMC-493 was sufficient for detection of GABA-A R, Epsilon in 20 µg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Antibody Specificity: Very high
Related Product 1: GABA-A Receptor Alpha2 pan-specific antibody (Cat. No.: AB-NN250-1)
Related Product 2: GABA-A Receptor Alpha4 pan-specific antibody (Cat. No.: AB-NN251-1)
Related Product 3: GABA-A Receptor Alpha5 pan-specific antibody (Cat. No.: AB-NN252-1)
Related Product 4: GABA-A Receptor Beta1 pan-specific antibody (Cat. No.: AB-NN253-1)
Related Product 5: GABA-A Receptor Beta3 pan-specific antibody (Cat. No.: AB-NN254-1)
Related Product 6: GABA-B Receptor 1 pan-specific antibody (Cat. No.: AB-NN259-1)
Related Product 7: GABA-B Receptor 2 pan-specific antibody (Cat. No.: AB-NN256-2)
Scientific Background: The GABA-A receptor is a member of the superfamily of fast acting ligand-gated ion channels. The individual subunits of these receptors have similar sequences and structural features (1). GABA-A receptors are the major fast inhibitory neurotransmitter gated ion channels in the brain (2). Brainstem expression of GABA-A Receptor, Epsilon, is upregulated during pregnancy (3).