Product Name:
BDNF
Product Number:
ab-nn216-1
Target Full Name: Brain-derived neurotrophic factor
Target Alias: Abrineurin; ANON2; BDNF_Human; MGC34632
Product Type Specific: Growth factor protein pan-specific antibody
Antibody Code: NN216-1
Antibody Target Type: Pan-specific
Protein UniProt: P23560
Protein SigNET: BDNF
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Antibody Ig Isotype Clone: N/A
Antibody Immunogen Source: Synthetic peptide patterned after N-terminal of human BDNF
Production Method: Peptide Affinity purified
Antibody Modification: Unconjugated. Contact KInexus if you are interest in having the antibody biotinylated or coupled with fluorescent dyes.
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline, 50% glycerol, 0.09% sodium azide
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting
Antibody Dilution Recommended: WB (1:1000); optimal dilutions for assays should be determined by the user.
Antibody Potency: Predicted molecular mass at ~27.9 kDa.
Antibody Species Reactivity: This antibody detects the target protein in the following species due to conservation of amino acid sequence: Human | Mouse .
Antibody Specificity: Very high
Scientific Background: BDNF (Brain-derived neurotrophic factor) is a secreted cytokine that belongs to the NGF-beta family, and activates signaling cascades downstream of NTRK2. It activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2. Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD). Binding to NGFR and SORCS2 promotes neuronal apoptosis and neuronal growth cone collapse. During development, it promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. It participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. It is a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. It contributes to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. It is present in blood plasma and in saliva. In the brain, it is highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. It is also found in heart, lung, skeletal muscle, testis, prostate and placenta. This description may include information annotated by UniProt and/or Google AI.