Product Name:
PDK2-3
Product Number:
ab-nn180-2
Target Full Name: Pyruvate dehydrogenase kinase isoform 2; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial
Target Alias: Kinase Pyruvate dehydrogenase kinase 2; PDK2; Pyruvate dehydrogenase [lipoamide] kinase isozyme 2, mitochondrial precursor
Product Type Specific: Protein kinase pan-specific antibody
Antibody Code: NN180-2
Antibody Target Type: Pan-specific
Protein UniProt: Q15119
Protein SigNET: Q15119
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Antibody Immunogen Source: Human PDK2 (PDHK2) sequence peptide Cat. No.: PE-01BAB85
Antibody Immunogen Sequence: CDKYYMASPDLEIQEI
Antibody Immunogen Description: Corresponds to amino acid residues C212 to I227
Production Method: Corresponds to amino acid residues C212 to I227
Antibody Modification: Protein kinase pan-specific antibody
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH 7.4, 0.05% Thimerasol
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Antibody microarray
Antibody Dilution Recommended: 1 µg/ml for immunoblotting
Antibody Potency: Medium immunoreactivity with recombinant human PDK2 on protein dot blots.
Antibody Species Reactivity: Human; Mouse
Antibody Positive Control: The observed molecular mass of the processed target protein on SDS-PAGE gels is reported to be around 42-50 kDa.
Antibody Specificity: High
Antibody Cross Reactivity: No immunoreactivity on protein dot blots with recombinant human PDK1, PDK3 and PDK4.
Related Product 1: PDK2-3 blocking peptide
Related Product 2: PDK2-1 pan-specific antibody (Cat. No.: AB-NN180-1)
Related Product 3: PDHKSubtide - PDHK protein kinase substrate peptide
Scientific Background: PDHK2 (PDK2, pyruvate dehydrogenase kinase 2) is a protein-serine/threonine kinase of the Atypical group and PDHK family. It is an essential kinase in the regulation of fatty acid and glucose metabolism by phosphorylating and inactivating the enzyme pyruvate dehydrogenase.
