Product Name:
PDK4-3
Product Number:
ab-nn178-3
Target Full Name: Pyruvate dehydrogenase kinase isoform 4; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial
Target Alias: Pyruvate dehydrogenase kinase isoform 4; PDK4;
Product Type Specific: Protein kinase pan-specific antibody
Antibody Code: NN178-3
Antibody Target Type: Pan-specific
Protein UniProt: Q16654
Protein SigNET: Q16654
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Antibody Immunogen Source: Human PDK4 (PDHK4) sequence peptide Cat. No.: PE-01ARK90
Antibody Immunogen Sequence: CDQYYLSSPELKLTQV
Antibody Immunogen Description: Corresponds to amino acid residues C215 to V230
Production Method: Corresponds to amino acid residues C215 to V230
Antibody Modification: Protein kinase pan-specific antibody
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH 7.4, 0.05% Thimerasol
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Antibody microarray
Antibody Dilution Recommended: 2 µg/ml for immunoblotting
Antibody Species Reactivity: Human; Mouse
Antibody Positive Control: The observed molecular mass of the processed target protein on SDS-PAGE gels is reported to be around 45-55 kDa.
Antibody Specificity: Very high
Antibody Cross Reactivity: No immunoreactivity on protein dot blots with recombinant human PDK1, PDK3 and PDK4.
Related Product 1: PDK4-3 blocking peptide
Related Product 2: PDK4 pan-specific antibody (Cat. No.: AB-NN178-1)
Related Product 3: PDK4 pan-specific antibody (Cat. No.: AB-NN178-2P)
Related Product 4: PDK4 pan-specific antibody (Cat. No.: AB-NN178-3P)
Related Product 5: PDK4-1 pan-specific antibody (Cat. No.: AB-NN178-2)
Related Product 6: PDHKSubtide - PDHK protein kinase substrate peptide
Scientific Background: PDHK4 (PDK4, pyruvate dehydrogenase kinase 4) is a protein-serine/threonine kinase of the Atypical group and PDHK family. It phosphorylates and inactivates the enzyme pyruvate dehydrogenase. Deficiency of PDHK4 attenuates the long-term negative effects of a high-saturated fat diet.
