Product Name:
Nrf2
Product Number:
ab-nn140-1
Target Full Name: Nuclear factor erythroid 2-related factor 2
Target Alias: NFE2L2; HEBP1; NRF2
Product Type Specific: NRF2 (NFE2L2) transcription protein pan-specific antibody
Antibody Code: NN140-1
Antibody Target Type: Pan-specific
Protein UniProt: Q16236
Protein SigNET: Nrf2
Antibody Type: Polyclonal
Antibody Host Species: Goat
Antibody Immunogen Source: Synthetic peptide patterned after human Nrf2
Antibody Immunogen Sequence: HSSRLEAHLTRDE
Antibody Immunogen Description: Corresponds to amino acid residues H445-E458.
Production Method: Affinity purified
Antibody Modification: Unconjugated. Contact KInexus if you are interest in having the antibody biotinylated or coupled with fluorescent dyes.
Storage Buffer: TBS, pH7.3, 0.02% sodium azide, 0.5% BSA
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: ELISA, Western blotting
Antibody Dilution Recommended: 1:500-1500 (WB), 1:64000 (ELISA)
Antibody Species Reactivity: This antibody detects the target protein in the following species due to conservation of amino acid sequence: Human | Chimpanzee | Rhesus macaque | Cow | Dog | Pig | Rat | Mouse.
Antibody Positive Control: A 1:1500 dilution of SPC-218 was sufficient for detection of Nrf2 in 35 µg of human lung lysate by electrochemiluminescence analysis using donkey anti-goat IgG:HRP as the secondary antibody.
Scientific Background: Nrf2 is a transcription factor which plays a role in the oxidative stress response. Under normal cellular conditions, it is sequestered in the cytoplasm by Keap1 and Cullin3. When under oxidative stress, Nrf2 is release from Keap1 by p62 and is translocated to the nucleus where it acts as a transcription factor for the expression of oxidative stress-related products. This description may include information annotated by UniProt and/or Google AI.