Product Name:
Hsc70 (HSP73)
Product Number:
ab-nn054-3
Target Full Name: Heat shock cognate 71 kDa protein
Target Alias: Heat shock 70 kDa protein 8; HS7C; HSP73; HSP7C; HSPA10
Product Type Specific: Pan-specific monoclonal antibody for human Hsc70 (HSP73)
Antibody Code: NN054-3
Antibody Target Type: Pan specific
Protein UniProt: P11142
Protein SigNET: P11142
Antibody Type: Monoclonal
Antibody Host Species: Mouse
Antibody Ig Isotype Clone: 1F2-H5/IgG2a Kappa
Antibody Immunogen Source: Human Hsc70.
Antibody Modification: Pan-specific monoclonal antibody for human Hsc70 (HSP73)
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline, pH 7.4, 50% glycerol, 0.09% sodium azide
Storage Conditions: -20°C
Storage Stability: > 1 year
Product Use: Western blotting, Enzyme-linked immunosorbent assays (ELISA), Immunoprecipitation (IP), Immunohistochemistry (IHC)
Antibody Potency: Very strong
Antibody Species Reactivity: Human, Mouse, Rat Other species not yet tested
Antibody Specificity: Very high
Antibody Cross Reactivity: Target protein strongly detected in only rat testes. No detectable cross-reactivities in test blots.
Scientific Background: Hsc70 (HSP73) is a member of the HSP70 family that acts as a repressor of transcriptional activation. Isoform 2 of Hsc70 may function as an endogenous inhibitory regulator of Hsc70 by competing with co-chaperones. It interacts with BAG1, DNAJC7, HERC5, HSPH1/HSP105, IRAK1BP1, PACRG, SV40 VP1, and TSC2, and can be found in a mRNP granule complex. Hsc70 also binds CITED1 and this interaction suppresses the association of CITED1 to p300/CBP and Smad-mediated transcription transactivation. Upon DNA damage, Hsc70 undergoes increased phosphorylation, apparently by ATM or ATR.
