Product Name:
FGFR4-4
Product Number:
ab-nk239-3
Target Full Name: Fibroblast growth factor receptor 4
Target Alias: CD334; JTK2; MGC20292; MPK11; TKF; CCDS4411.1; ENSG00000160867
Product Type Specific: Protein kinase pan-specific antibody
Antibody Code: NK239-3
Antibody Target Type: Pan-specific
Protein UniProt: P22455
Protein SigNET: P22455
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Antibody Immunogen Source: Human FGFR4 sequence peptide Cat. No.: PE-01BBW99
Antibody Immunogen Sequence: CSNDDEDPKSHRDPSN
Antibody Immunogen Description: Corresponds to amino acid residues S124 to N138
Production Method: Corresponds to amino acid residues S124 to N138
Antibody Modification: Protein kinase pan-specific antibody
Antibody Concentration: 0.19 / 0.4 mg/ml
Storage Buffer: Phosphate buffered saline pH 7.4, 0.05% Thimerasol
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Antibody microarray
Antibody Dilution Recommended: 2 µg/ml for immunoblotting
Antibody Potency: Weak reactivity with recombinant human FGFR4 on protein dot blots.
Antibody Species Reactivity: Human
Antibody Positive Control: The observed molecular mass of the processed target protein on SDS-PAGE gels is reported to be around 85-105 kDa.
Antibody Specificity: Very high
Antibody Cross Reactivity: No immunoreactivity on protein dot blots with recombinant human FGFR1 and FGFR2.
Related Product 1: FGFR4-4 blocking peptide
Related Product 2: FGFR4-2 pan-specific antibody (Cat. No.: AB-NK239-1)
Scientific Background: FGFR4 is a protein-tyrosine kinase of the TK group and FGFR family. It is a receptor kinase that is involved in recognizing fibroblast growth factors to control cell migration, differentiation, proliferation, and regulating lipid metabolism. It is activated by binding of fibroblast growth factor (FGF), which induces dimerization and autophosphorylation. Interaction with PLCG1 with FGFR4 is mediated through autophosphorylation of Y754. FGFR4 may be an oncoprotein (OP). Defects in FGFR4 have been linked to alveolar rhabdomyosarcomas (ARMS), breast fibroadenomas, gliomatosis cerebri, and anaplastic astrocytomas.
