Product Name:
ErbB3
Product Number:
ab-nk231-2p
Target Full Name: ErbB3 (HER3) receptor-tyrosine kinase
Target Alias: C-erbB3; ERB3; HER3; Kinase ErbB3; LCCS2; Receptor protein-tyrosine kinase erbB-3 precursor; Tyrosine kinase-type cell surface receptor HER3; V-erb-b2 erythroblastic leukemia viral oncogene 3; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; MGC88033; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; ENSG00000065361; O75810; O75811; O75812; O75813; Q9BUD7; Q9NNX2; Q9NNX3
Product Type Specific: Protein kinase pan-specific antibody
Antibody Code: NK231-2P
Antibody Target Type: Pan-specific
Protein UniProt: P21860
Protein SigNET: P21860
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Antibody Immunogen Source: Human ErbB3 (HER3) sequence peptide Cat. No.: PE-01ARS99
Antibody Immunogen Sequence: DRDAEIVVKDNGRSC
Antibody Immunogen Description: Corresponds to amino acid residues D169 to C183
Production Method: Corresponds to amino acid residues D169 to C183
Antibody Modification: Protein kinase pan-specific antibody
Storage Buffer: Phosphate buffered saline pH 7.4, 0.05% Thimerasol
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Antibody microarray
Antibody Dilution Recommended: 2 µg/ml for immunoblotting
Antibody Potency: Very strong immunoreactivity with recombinant human ErbB3 on protein dot blots.
Antibody Species Reactivity: Human; Mouse; Rat
Antibody Positive Control: The observed molecular mass of the processed target protein on SDS-PAGE gels is reported to be around 160-200 kDa.
Antibody Specificity: Medium
Antibody Cross Reactivity: No immunoreactivity on protein dot blots with recombinant human ErbB2 and ErbB4.
Related Product 1: ErbB3 blocking peptide
Related Product 2: ErbB3-1 pan-specific antibody (Cat. No.: AB-NK231-2)
Related Product 3: ErbB3-2 pan-specific antibody (Cat. No.: AB-NK231-3)
Related Product 4: ErbB3-3 pan-specific antibody (Cat. No.: AB-NK231-4)
Related Product 5: ErbB3-pY1289 phosphosite-specific antibody (Cat. No.: AB-PK616)
Related Product 6: ErbB3-pY1307 phosphosite-specific antibody (Cat. No.: AB-PK617)
Related Product 7: ErbB3-pY1328 phosphosite-specific antibody (Cat. No.: AB-PK618)
Scientific Background: ErbB3 (HER3) is a protein-tyrosine kinase of the TK group and EGFR family. It is a receptor kinase that bind and be activated by NTAK and neuregulins. It has been proposed to be deficient in phosphotransferase activity. While the kinase domain appararently lacks activity but heterodimerizes with other EGFRs permits transduction of growth signals. Phosphorylation of Y1222 and Y1260 induces interaction with PIK3C and PIK3R1. ErbB3 appears to be up-regulated in many cancer, including medulloblastomas, verrucous carcinomas, childhood medulloblastomas, carotid body tumours (CBT), and gestational trophoblastic tumours (GTD).