Product Name:
Tyk2-3
Product Number:
ab-nk181-5
Target Full Name: Protein-tyrosine kinase 2 (Jak-related)
Target Alias: JTK1; Kinase Tyk2; Tyrosine kinase 2; CCDS12236.1; ENSG00000105397
Product Type Specific: Protein kinase pan-specific antibody
Antibody Code: NK181-5
Antibody Target Type: Pan-specific
Protein UniProt: P29597
Protein SigNET: P29597
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Antibody Immunogen Source: Human Tyk2 sequence peptide Cat. No.: PE-01AVL80
Antibody Immunogen Sequence: CWETEASFRPTFENLI
Antibody Immunogen Description: Corresponds to amino acid residues C1151 to I1166; Kinase last alpha-chain
Production Method: Corresponds to amino acid residues C1151 to I1166; Kinase last alpha-chain
Antibody Modification: Protein kinase pan-specific antibody
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH 7.4, 0.05% Thimerasol
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Antibody microarray
Antibody Dilution Recommended: 2 µg/ml for immunoblotting
Antibody Potency: Weak reactivity with recombinant human Tyk2 on protein dot blots.
Antibody Species Reactivity: Human
Antibody Positive Control: The observed molecular mass of the processed target protein on SDS-PAGE gels is reported to be around 130-140 kDa.
Antibody Specificity: Medium
Antibody Cross Reactivity: Very weak immunoreactivity on protein dot blots with recombinant human JAK3. No immunoreactivity on protein dot blots with recombinant human JAK1 and JAK2.
Related Product 1: Tyk2-3 blocking peptide
Related Product 2: Tyk2-1 pan-specific antibody (Cat. No.: AB-NK181-3)
Related Product 3: Tyk2-pY1054+pY1055 phosphosite-specific antibody (Cat. No.: AB-PK845)
Scientific Background: Tyk2 is a protein-tyrosine kinase of the TK group and JakA family. Phosphorylation of Y1054 and Y1055 increases phosphotransferase activity. Tyk2 mediates intracellular signal transduction from Type I interferon-alpha/beta receptor (IFN) signalling and phosphorylates the interferon-alpha/beta receptor alpha chain. Missense mutations in this gene have been found in colon and ovarian tumours.
