Product Name:
TAK1-CT (TAK1-4)
Product Number:
ab-nk181-3
Target Full Name: TGF-beta-activated protein-serine kinase 1; Mitogen-activated protein kinase kinase kinase 7
Target Alias: M3K7; MAP3K7; MEKK7; TGF1a; TGF-beta-activated kinase 1; TGF1a; ENSG00000135341
Product Type Specific: Protein kinase pan-specific antibody
Antibody Code: NK175-3
Antibody Target Type: Pan-specific
Protein UniProt: O43318
Protein SigNET: O43318
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Antibody Immunogen Source: Human TAK1 sequence peptide Cat. No.:
Antibody Immunogen Description: C-terminus
Production Method: C-terminus
Antibody Modification: Protein kinase pan-specific antibody
Antibody Concentration: 1 mg/ml
Storage Buffer: 100 mM Tris-glycine, pH 7.0
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months, but either 0.1% sodium azide or 0.05% Thimerasol should be added. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Antibody microarray
Antibody Dilution Recommended: 2 µg/ml for immunoblotting
Antibody Species Reactivity: Human; Rat
Antibody Positive Control: The observed molecular mass of the processed target protein on SDS-PAGE gels is reported to be around 67-85 kDa.
Related Product 1: TAK1-pS439 phosphosite-specific antibody (Cat. No.: AB-PK824)
Related Product 2: TAK1-pT184+pT187 phosphosite-specific antibody (Cat. No.: AB-PK825)
Scientific Background: TAK1 (MAP3K7, MEKK7) is a protein-serine/threonine kinase of the TKL group and MLK family. TAK1 is activated by proinflammatory cytokines and in response to physical/chemical stress, including UVR, osmotic- and oxidative stress. It is a mediator of TRAF6 and TGF-beta signal transduction, and activates IKBKB and MAPK8 in response to TRAF6 signalling. It also stimulates NFκB activation and activation of the p38 MAPK (MAPK8) pathway. It is responsible for controlling a variety of cell functions such as transcription and apoptosis. It regulates hepatic cell survival and carcinogenesis. TAK1 is important for TGF-beta1 regulation of MMP9 and the metastatic potential of certain breast cancer cell lines. It is activated by phosphorylation at T178, T184, T187 and S192. It is also activated by K63-linked polyubiquitination. TAK1 plays a role in tumour initiation, progression, and metastasis such as in breast cancer as a tumour inducer or tumour suppression depending on the cancer.
