Product Name:
Plk3-AKCD
Product Number:
ab-nk147-2
Target Full Name: Polo-like protein-serine kinase 3 (cytokine- inducible kinase (CNK))
Target Alias: CNK; Cytokine-inducible serine/threonine-protein kinase; FGF-inducible kinase; FNK; Kinase Plk3; Plk-3; Polo-like kinase 3; PRK; Proliferation-related kinase; RP11-269F19_6; CCDS515.1; ENSG00000173846
Product Type Specific: Protein kinase pan-specific antibody
Antibody Code: NK147-2
Antibody Target Type: Pan-specific
Protein UniProt: Q9H4B4
Protein SigNET: Q9H4B4
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Antibody Immunogen Source: Human Plk3 (CNK) sequence peptide Cat. No.: PE-01BFA75
Antibody Immunogen Sequence: KSKNHAQERDEVSGLVSGC
Antibody Immunogen Description: Corresponds to amino acid residues K357 to G374; After catalytic domain
Production Method: Corresponds to amino acid residues K357 to G374; After catalytic domain
Antibody Modification: Protein kinase pan-specific antibody
Antibody Concentration: 0.18 mg/ml
Storage Buffer: Phosphate buffered saline pH 7.4, 0.05% Thimerasol
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Antibody microarray
Antibody Dilution Recommended: 2 µg/ml for immunoblotting
Antibody Potency: Weak immunoreactivity of a target-sized protein by Western blotting in A431 cells
Antibody Species Reactivity: Human
Antibody Positive Control: The observed molecular mass of the processed target protein on SDS-PAGE gels is reported to be around 72-78 kDa.
Antibody Specificity: Very high
Antibody Cross Reactivity: No significant cross-reactivities detected in various human cancer cell lines, including A431, HEK-293, HeLa, HepG2, Jurkat and MCF7 cells. No cross-reactivities detected in mouse brain, skeletal muscle, testes and thymus.
Related Product 1: Plk3-AKCD blocking peptide
Related Product 2: Plk3Subtide - Plk3 (CNK) protein kinase substrate peptide
Scientific Background: Plk3 (CNK) is a protein-serine/threonine kinase of the Other group and Plk family. It plays a role in cell cycle regulation and tumourigenesis. Overexpression of Plk3 leads to mitotic arrest, cytokinesis defects, and apoptosis. Polymorphisms of Plk3 gene have been identified in human lung carcinoma cell lines.