Product Name:
p38d-3
Product Number:
ab-nk121-3
Target Full Name: Mitogen-activated protein-serine kinase p38 delta; Mitogen-activated protein kinase 13
Target Alias: MAP kinase p38 delta; MAPK13; Mitogen-activated protein kinase p38 delta; MK13; P38 MAPK-delta;p38delta; PRKM13; Stress-activated protein kinase-4; SAPK4; p38d MAPK; ENSG00000156711
Product Type Specific: Protein kinase pan-specific antibody
Antibody Code: NK121-4
Antibody Target Type: Pan-specific
Protein UniProt: O15264
Protein SigNET: O15264
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Antibody Immunogen Source: Human p38d MAPK (MAPK13) sequence peptide Cat. No.: PE-01AYI90
Antibody Immunogen Sequence: CPIARKDSRRRSGMKL
Antibody Immunogen Description: Corresponds to amino acid residues P351 to L365; C-terminus
Production Method: Corresponds to amino acid residues P351 to L365; C-terminus
Antibody Modification: Protein kinase pan-specific antibody
Antibody Concentration: 0.75 mg/ml
Storage Buffer: Phosphate buffered saline pH 7.4, 0.05% Thimerasol
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Antibody microarray
Antibody Dilution Recommended: 1 µg/ml for immunoblotting
Antibody Potency: Medium immunoreactivity with recombinant human p38d on protein dot blots.
Antibody Species Reactivity: Human; Mouse
Antibody Positive Control: The observed molecular mass of the processed target protein on SDS-PAGE gels is reported to be around 37-45 kDa.
Antibody Specificity: High
Antibody Cross Reactivity: Weak immunoreactivity on protein dot blots with recombinant human p38g and p38b, and no immunoreactivity with p38a.
Related Product 1: p38d-3 blocking peptide
Related Product 2: p38 pan-specific antibody (Cat. No.: AB-NK120-5)
Related Product 3: p38d-1 pan-specific antibody (Cat. No.: AB-NK121-2)
Related Product 4: p38d-2 pan-specific antibody (Cat. No.: AB-NK121-3)
Related Product 5: p38d-pT180+pY182 phosphosite-specific antibody (Cat. No.: AB-PK742)
Related Product 6: p38d-pY182 phosphosite-specific antibody (Cat. No.: AB-PK743)
Related Product 7: p38SelectideA - p38a MAPK (MAPK14) protein kinase substrate peptide
Related Product 8: p38Subtide - p38a MAPK (MAPK14) protein kinase substrate peptide
Related Product 9: p38 MAPK KinSub - p38 MAPK peptide substrate
Scientific Background: p38d (MAPK13) is a protein-serine/threonine kinase of the CMGC group and MAPK family. It is essential for MAP kinase signalling that can be induced via physical stress or proinflammatory cytokines. It is activated by phosphorylation at Y182 and probably T180 by (MKK3 (MAP2K3) and MKK6 (MAP2K6). p38d signalling can be induced via physical stress or proinflammatory cytokines resulting in the activation of the transcription factors ELK1 and ATF2. It can affect proliferation, differentiation, transcription regulation, translation regulation, cytoskeleton regulation, insulin secretion, cell survival and development. p38d can be a positive or negative regulator of the above processes depending on the cell context. Increased expression of p38d has been associated with increases proliferation and metastatic progression. It is also hypermethylated in some cancer cell lines. The rare liver cancer Cholangiocarcinoma (CCA, CC) has been noted to have a significant up-regulation of p38d compared to normal bile duct tissue. Insulin secretion and pancreatic beta cell survival can be regulated by p38d.
