Product Name:
Ksr1
Product Number:
ab-nk087-2
Target Full Name: Protein-serine kinase suppressor of Ras 1
Target Alias: CAP kinase; Ceramide-activated protein kinase; HB; HB protein; Ksr; Ksr1; Kinase suppressor of ras 1; Kinase suppressor of RAS-1; RSU2; ENSG00000141068
Product Type Specific: Protein kinase pan-specific antibody
Antibody Code: NK090
Antibody Target Type: Pan-specific
Protein UniProt: Q8IVT5
Protein SigNET: Q8IVT5
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Antibody Immunogen Source: Human Ksr1 sequence peptide
Antibody Immunogen Sequence: EKLPKLNRRLSHPGHFWKSC
Antibody Immunogen Description: Corresponds to amino acid residues E829 to S847; C-terminus
Production Method: Corresponds to amino acid residues E829 to S847; C-terminus
Antibody Modification: Protein kinase pan-specific antibody
Storage Buffer: 100 mM Tris-glycine, pH 7.0
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months, but either 0.1% sodium azide or 0.05% Thimerasol should be added. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Antibody microarray
Antibody Dilution Recommended: 2 µg/ml for immunoblotting
Antibody Species Reactivity: Human; Mouse; Rat
Antibody Positive Control: The observed molecular mass of the processed target protein on SDS-PAGE gels is reported to be around 105-120 kDa.
Related Product 1: Ksr1-pS406 phosphosite-specific antibody (Cat. No.: AB-PK675)
Related Product 2: Ksr2-pS490 phosphosite-specific antibody (Cat. No.: AB-PK676)
Scientific Background: Ksr1 (kinase suppressor of Ras 1) is a protein-serine/threonine kinase of the TKL group and RAF family. It is a Raf-related pseudokinase and may directly mediate Raf activation. It acts as a scaffold for the Raf/MEK/ERK kinase cascade. No specific mutations have been directly implicated in oncogenesis although loss of Ksr1 function will blunt the Ras pathway and therefore attenuate its oncogenic potential.