Product Name:
TAOK3-AKCD
Product Number:
ab-nk086-3
Target Full Name: Serine/threonine-protein kinase TAO3
Target Alias: DPK; JIK; Kinase TAO3; MAP3K18; TAO kinase 3; TAOK3
Product Type Specific: Protein kinase pan-specific antibody
Antibody Code: NK087-2
Antibody Target Type: Pan-specific
Protein UniProt: Q9H2K8
Protein SigNET: Q9H2K8
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Antibody Immunogen Source: Human TAOK3 (JIK, TAO3) sequence peptide Cat. No.: PE-01BFJ
Antibody Immunogen Sequence: CSEHGTSLNREMDSLGSNHS
Antibody Immunogen Description: Corresponds to amino acid residues S331 to S349; After catalytic domain
Production Method: Corresponds to amino acid residues S331 to S349; After catalytic domain
Antibody Modification: Protein kinase pan-specific antibody
Antibody Concentration: 0.43 mg/ml
Storage Buffer: Phosphate buffered saline pH 7.4, 0.05% Thimerasol
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Antibody microarray
Antibody Dilution Recommended: 2 µg/ml for immunoblotting
Antibody Species Reactivity: Human
Antibody Positive Control: The observed molecular mass of the processed target protein on SDS-PAGE gels is reported to be around 115-125 kDa.
Antibody Specificity: Very high
Antibody Cross Reactivity: No cross-reactivities detected in mouse brain, skeletal muscle, testes and thymus, or in various human cancer cell lines, including A431, HEK-293, HeLa, HepG2, Jurkat and MCF7 cells.
Related Product 1: TAOK3-AKCD blocking peptide
Related Product 2: TAOSubtide - TAOK2 (PSK) protein kinase substrate peptide
Scientific Background: TAO3 (MAP3K18, TAOK3) is a protein-serine/threonine kinase of the STE group and STE20 family. It is a cutaneous T-cell lymphoma-associated antigen. It also functions in the G2-M transition in response to DNA damage. Insertional mutagenesis studies in mice support a role for this protein kinase in mouse cancer oncogenesis.
